检验医学与临床2025，Vol.22Issue(18)：2458-2463,6.DOI:10.3969/j.issn.1672-9455.2025.18.002
老年重症肺炎并发呼吸衰竭患者血清NAMPT、suPAR水平及其对预后的预测价值
Serum levels of NAMPT and suPAR and their prognostic value in elderly patients with severe pneumonia complicated by respiratory failure
摘要
Abstract
Objective To investigate the predictive value of serum levels of nicotinamide phosphoribosyl-transferase(NAMPT)and soluble urokinase-type plasminogen activator receptor(suPAR)for 30 d mortality after admission in elderly patients with severe pneumonia(SP)complicated by respiratory failure(RF).Meth-ods A total of 164 elderly patients with SP complicated by RF treated at the hospital from December 2020 to December 2023 were selected as the study group,while 164 healthy individuals undergoing physical examina-tions in the hospital during the same period were selected as the control group.Based on the Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,the study group was stratified into low-risk,medium-risk,and high-risk groups.All patients were followed for 30 d starting from admission and were divided into the death group and survival group based on their survival status.Serum levels of NAMPT and suPAR were measured using enzyme-linked immunosorbent assay(ELISA).Spearman correlation analysis was employed to assess the correlation between serum NAMPT,suPAR levels and disease severity in elderly SP patients with RF.Multivariate Logistic regression analysis was used to identify factors influencing 30 d mortality.The predictive value of serum NAMPT and suPAR for 30 d mortality was evaluated by receiver operating charac-teristic(ROC)curve analysis.Results Compared with the control group,serum NAMPT and suPAR levels were significantly higher in the study group(P＜0.05).Compared with the low-risk group,NAMPT and su-PAR levels were elevated in both the medium-risk and high-risk groups(P＜0.05).Furthermore,NAMPT and suPAR levels were significantly higher in the high-risk group compared with the medium-risk group(P＜0.05).Serum NAMPT and suPAR levels were positively correlated with disease severity(rs=0.428,0.313,both P＜0.05).NAMPT and suPAR levels in the death group were significantly higher compared with the survival group(P＜0.05).Statistically significant differences were found between the survival and death groups regarding the proportion requiring mechanical ventilation and APACHE Ⅱ scores(P＜0.05).Multiva-riate Logistic regression analysis identified NAMPT,suPAR and mechanical ventilation as independent factors influencing 30 d mortality(P＜0.05).The area under the curve for the combination of serum NAMPT and suPAR in predicting 30 d mortality was significantly greater than that of NAMPT alone(Zcombined vs.NAMPT=2.176,P=0.030)or suPAR alone(Zcombined vs.suPAR=2.398,P=0.017).Conclusion Serum levels of NAMPT and suPAR are significantly elevated in elderly patients with SP complicated by RF,and the combination de-tection of these two biomarkers enhances the predictive value for 30 d mortality in these patients.关键词
重症肺炎/呼吸衰竭/烟酰胺磷酸核糖基转移酶/可溶性尿激酶型纤溶酶原激活物受体/老年Key words
severe pneumonia/respiratory failure/nicotinamide phosphoribosyltransferase/soluble urokinase-type plasminogen activator receptor/elderly分类
医药卫生引用本文复制引用
杨君莉,蒋艳敏,李娜,韩晓楠,张颖..老年重症肺炎并发呼吸衰竭患者血清NAMPT、suPAR水平及其对预后的预测价值[J].检验医学与临床,2025,22(18):2458-2463,6.基金项目
河北省医学科学研究重点课题计划项目(20201370). （20201370）
