检验医学与临床2025，Vol.22Issue(18)：2464-2468,2474,6.DOI:10.3969/j.issn.1672-9455.2025.18.003
血清LTB4、ANGPTL4对慢性阻塞性肺疾病急性加重期患者预后不良的预测价值
Predictive value of serum LTB4 and ANGPTL4 for poor prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To evaluate the predictive value of serum leukotriene B4(LTB4)and angiopoietin-like 4(ANGPTL4)for prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 106 patients with AECOPD admitted to Handan 285 Hospital from July 2022 to March 2024 were enrolled as the AECOPD group,and 115 healthy individuals undergoing routine physical examinations in Handan 285 Hospital during the same period were recruited as the control group.Se-rum LTB4 and ANGPTL4 levels were quantified using enzyme-linked immunosorbent assay(ELISA).Forced vital capacity(FVC),percentage of predicted forced expiratory volume in one second(FEV1％pred)and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)were measured with a spirometer.Arterial partial pressure of oxygen(PaO2)and carbon dioxide(PaCO2)were analyzed using blood gas electrolyte analyzers.All patients were with 3-month follow-up after discharge,and they were stratified in-to the good-prognosis group and poor-prognosis group based on clinical outcomes.Multivariate Logistic re-gression analysis was applied to identify factors influencing poor prognosis.Receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of serum LTB4 and ANGPTL4 for poor prognosis of AECOPD.Results Compared with the control group,serum LTB4,ANGPTL4 and levels PaCO2 were significantly elevated(P＜0.05),while PaO2,FEV1％pred and FEV1/FVC in the AECOPD group were reduced(P＜0.05).Among 106 AECOPD patients,68 were classified as good-prognosis and 38 as poor-prog-nosis.There were no statistically significant differences between the prognosis groups in PaO2,age,PaCO2,BMI,white blood cell count,smoking history,FEV1％pred,FEV1/FVC,comorbidities,gender,COPD dura-tion,or neutrophil count(P＞0.05).Serum LTB4 and ANGPTL4 levels,along with APACHE Ⅱ scores in the poor-prognosis group were significantly higher than those in the good-prognosis group(P＜0.05).Multivari-ate Logistic regression analysis identified LTB4 and ANGPTL4 as independent predictors of poor prognosis(P＜0.05).Areas under the receiver-operating-characteristic curve for predicting poor prognosis were 0.804 for LTB4,0.797 for ANGPTL4 and 0.907 for their combination;the combined model showed significantly better predictive performance than either biomarker alone(P＜0.05).Conclusion Elevated serum LTB4 and ANGPTL4 levels in patients with AECOPD demonstrate predictive value for poor prognosis.关键词
慢性阻塞性肺疾病急性加重期/白三烯B4/血管生成素样蛋白4/预后/预测价值Key words
acute exacerbation of chronic obstructive pulmonary disease/leukotriene B4/angiopoietin-like 4/prognosis/predictive value分类
医药卫生引用本文复制引用
常秀明,柴书坤,沈丽晓,武书叶..血清LTB4、ANGPTL4对慢性阻塞性肺疾病急性加重期患者预后不良的预测价值[J].检验医学与临床,2025,22(18):2464-2468,2474,6.基金项目
河北省卫生健康委员会资助项目(20241354). （20241354）
