检验医学与临床2025，Vol.22Issue(18)：2493-2497,2503,6.DOI:10.3969/j.issn.1672-9455.2025.18.008
血清SLC7A11、TIMP4对阵发性心房颤动患者射频消融术后复发的预测价值
Predictive value of serum SLC7A11 and TIMP4 for recurrence after radiofrequency ablation in patients with paroxysmal atrial fibrillation
摘要
Abstract
Objective To investigate the predictive value of serum solute carrier family 7 member 11(SLC7A11)and tissue inhibitor of metalloproteinase 4(TIMP4)for post-ablation recurrence in patients with paroxysmalatrial fibrillation(PAF)undergoing radiofrequency ablation(RFA).Methods A total of 193 PAF patients undergoing RFA at this hospital between January 2022 and June 2023 were enrolled in the PAF group,while 120 healthy individuals who underwent physical examination during the same period at this hos-pital were assigned to the control group.Based on post-RFA recurrence status,PAF patients were stratified into the recurrence group and non-recurrence group.Serum SLC7A11 and TIMP4 levels were quantified across all groups using enzyme-linked immunosorbent assay(ELISA).Multivariate Logistic regression analysis was performed to identify influencing factors for post-RFA recurrence in PAF patients.Receiver operating charac-teristic(ROC)curve was generated to evaluate the predictive value of serum SLC7A11 and TIMP4 for post-RFA recurrence.Results Serum levels of SLC7A11 and TIMP4 in the PAF group were lower than those in the control group(P＜0.05).The recurrence rate of 193 PAF patients one year after RFA was 31.09％(60/193).Serum levels of SLC7A11 and TIMP4 in the recurrence group were lower than those in the non-recur-rence group(P＜0.05).Independent risk factors for recurrence after RFA were longer disease duration,high-er CHA2DS2-VASc score,and larger left atrial diameter(P＜0.05).Independent protective factors were higher levels of SLC7A11 and TIMP4(P＜0.05).The area under the curve of combining serum SLC7A11 and TIMP4 to predict recurrence after RFA was greater than that of them individually(P＜0.05).Conclusion Lower serum SLC7A11 and TIMP4 levels characterize patients with PAF.These reductions are associated with recurrence after RFA,and the combined measurement of serum SLC7A11 and TIMP4 shows high predictive value for post-RFA recurrence in PAF.关键词
阵发性心房颤动/射频消融/溶质载体家族7成员11/组织金属蛋白酶抑制剂4/复发Key words
paroxysmal atrial fibrillation/radiofrequency ablation/solute carrier family 7 member 11/tissue inhibitor of metalloproteinases-4/recurrence分类
医药卫生引用本文复制引用
杨小兰,忽海洋,胡亚莉..血清SLC7A11、TIMP4对阵发性心房颤动患者射频消融术后复发的预测价值[J].检验医学与临床,2025,22(18):2493-2497,2503,6.基金项目
陕西省卫生健康委员会科研项目(2019D0043). （2019D0043）
