检验医学与临床2025，Vol.22Issue(18)：2510-2515,6.DOI:10.3969/j.issn.1672-9455.2025.18.011
慢性肾脏病患者血清VNN1、DKK1、FGF21水平与肾功能损伤程度的相关性
Correlation of serum VNN1,DKK1 and FGF21 levels with renal impairment in patients with chronic kidney disease
摘要
Abstract
Objective To detect serum vanin-1(VNN1),dickkopf-related protein 1(DKK1)and fibroblast growth factor 21(FGF21)levels in patients with chronic kidney disease(CKD),and to evaluate their correla-tions with the severity of renal impairment and their prognostic significance.Methods A total of 108 CKD pa-tients admitted to the hospital from January 2022 to June 2023 were enrolled as the CKD group and stratified by CKD stage into the mild group,moderate-to-severe group and renal failure group.Eighty healthy individu-als undergoing physical examinations in the hospital during the same period were selected as controls.Serum levels of VNN1,DKK1 and FGF21 were measured using enzyme-linked immunosorbent assay(ELISA).Blood urea nitrogen(BUN)and serum creatinine(SCr)were quantified with an automatic biochemical analyzer,fol-lowed by calculation of urinary albumin-to-creatinine ratio(UACR)and estimated glomerular filtration rate(eGFR).All patients were followed for one year and categorized into the good-prognosis group and poor-prog-nosis group based on clinical outcomes.Results Serum levels of VNN1,DKK1 and FGF21 were significantly higher in the CKD group compared with the control group(P＜0.05).In moderate-to-severe group and renal failure group,serum VNN1,DKK1,FGF21,BUN and SCr levels as well as UACR were significantly higher,while eGFR was significantly lower than those in the mild group(all P＜0.05).Serum VNN1,DKK1,FGF21,BUN and SCr levels as well as UACR in the renal failure group were significantly higher(P＜0.05),while eGFR was significantly lower compared with the moderate-to-severe group(P＜0.05).Spearman corre-lation analysis revealed significant positive correlations between serum VNN1,DKK1,FGF21 levels and CKD stage(P＜0.05).Pearson correlation analysis indicated significant positive correlations of these biomarkers with BUN,SCr and UACR(P＜0.05),and significant negative correlations with eGFR(P＜0.05).Follow-up results showed that,47 patients were categorized into the good-prognosis group and 61 into the poor-prognosis group.Serum VNN1,DKK1 and FGF21 levels in the poor-prognosis group were significantly higher than those in the good-prognosis group(P＜0.05).Elevated serum VNN1,DKK1 and FGF21 levels were identified as risk factors for poor prognosis in CKD patients(P＜0.05).The combined prediction model of serum VNN1,DKK1 and FGF21 yielded an area under the curve(AUC)of 0.902 for poor prognosis,significantly outperforming individual biomarker predictions(ZCombined-VNN1=2.277,P=0.023;ZCombind-DKK1=2.755,P=0.006;ZCombined-FGF21=2.413,P=0.016).Conclusion Elevated serum levels of VNN1,DKK1 and FGF21 in pa-tients with CKD are associated with the degree of renal impairment.Serum VNN1,DKK1 and FGF21 are fac-tors associated with poor prognosis in CKD patients.Combined detection of these biomarkers can improve pre-dict value for poor prognosis.关键词
慢性肾脏病/血管非炎性因子1/分泌型糖蛋白Dickkopf 1/成纤维细胞生长因子21/肾功能损伤Key words
chronic kidney disease/vanin-1/dickkopf-related protein 1/fibroblast growth factor 21/renal impairment分类
医药卫生引用本文复制引用
韩悦,隋丰旭,沈天一..慢性肾脏病患者血清VNN1、DKK1、FGF21水平与肾功能损伤程度的相关性[J].检验医学与临床,2025,22(18):2510-2515,6.基金项目
上海市崇明区可持续发展科技创新行动计划(CKY2024-28). （CKY2024-28）
