昆明医科大学学报2025，Vol.46Issue(9)：81-88,8.DOI:10.12259/j.issn.2095-610X.S20250909
绝经后T2DM患者炎症因子与骨密度和β-CTX的相关性及诊断效能分析
Correlation and Diagnostic Performance of Inflammatory Cytokines in Relation to Bone Mineral Density and β-CTX in Postmenopausal Women with Type 2 Diabetes Mellitus
摘要
Abstract
Objective To analyze the correlation between inflammatory factors and bone mineral density(BMD)as well as β-C-terminal telopeptide of type I collagen(β-CTX)in postmenopausal patients with type 2 diabetes mellitus(T2DM),and to evaluate the diagnostic efficacy of the inflammatory factors in postmenopausal T2DM patients with osteoporosis(OP).Methods A total of 538 postmenopausal women with T2DM,hospitalized in the Department of Endocrinology at the Third People's Hospital of Yunnan Province from October 1,2023 to August 31,2024,were screened,and 181 were ultimately included in the study.Based on bone mineral density,they were divided into the osteopenia group(86 patients,-2.5<T<-1.0)and the osteoporosis group(95 patients,T≤-2.5).Demographic data,inflammation-related indicators,bone metabolism markers,and other clinical parameters were collected and recorded.Results(1)The differences were statistically significant in age,duration of T2DM,body mass index(BMI),C-reactive protein(CRP),interleukin-6(IL-6),neutrophil-to-lymphocyte ratio(NLR),monocyte-to-lymphocyte ratio(MLR),systemic immune-inflammation index(SII),β-CTX,parathyroid hormone(PTH),and BMD at various sites between the two groups(P<0.05);(2)Spearman correlation analysis results indicated that CRP,IL-6,NLR,MLR,and SII were negatively correlated with bone mineral density(P<0.05),and in the osteoporosis group,CRP and IL-6 were positively correlated with β-CTX(P<0.05);(3)Multifactorial binary logistic regression analysis showed that CRP,IL-6,SII,age,and β-CTX were independent risk factors for the occurrence of OP in both groups(OR>1,B>0),while BMI was an independent protective factor for the occurrence of OP(OR<1,B<0);(4)ROC curve analysis showed that CRP,IL-6,NLR,MLR,and SII all demonstrated diagnostic efficacy for postmenopausal T2DM patients with osteoporosis,among which the combined detection model of CRP,IL-6,and SII exhibited the highest diagnostic efficacy.Conclusion Inflammatory markers are correlated with bone mineral density and β-CTX levels,and may have predictive value for diagnosing osteoporosis in postmenopausal T2DM patients.关键词
炎症因子/绝经后2型糖尿病/骨质疏松症/相关性/诊断效能Key words
Inflammatory factors/Postmenopausal type 2 diabetes mellitus/Osteoporosis/Correlation/Diagnostic efficacy分类
医药卫生引用本文复制引用
张凯歌,李若楠,陈家林,冯德萍,刘宇..绝经后T2DM患者炎症因子与骨密度和β-CTX的相关性及诊断效能分析[J].昆明医科大学学报,2025,46(9):81-88,8.基金项目
云南省科技计划项目(202001BA070001-213) （202001BA070001-213）
云南省教育厅科学研究基金(2024Y930) （2024Y930）
