昆明医科大学学报2025，Vol.46Issue(9)：89-97,9.DOI:10.12259/j.issn.2095-610X.S20250910
表皮生长因子基因遗传多态性与非小细胞肺癌的相关性研究
Correlation between Epidermal Growth Factor Gene Polymorphisms and Non-small Cell Lung Cancer
摘要
Abstract
Objective To investigate the correlation between single nucleotide polymorphisms(SNPs)of the EGF gene,including rs11569017(A>T),rs2237051(A>G),rs3733625(C>T),and rs4444903(A>G),and the risk of non-small cell lung cancer(NSCLC)in a Han population of Yunnan.Methods A total of 439 patients with NSCLC and 520 healthy controls were recruited in Yunnan Province between January 2022 and December 2023.Genotyping of four SNP loci in the EGF gene was performed using TaqMan probes,followed by analysis of allele,genotype,genetic model,and haplotype distribution frequencies between NSCLC and control groups.Stratified analyses were further conducted based on NSCLC pathological types and clinical stages.Results The rs2237051 locus showed significant differences in allele(P=0.011)and genotype(P=0.042)frequencies between the squamous cell carcinoma(SCC)group and the control group.The frequency of the A allele was lower in the SCC group than in the control group(OR=0.71,95%CI 0.54～1.85),but there was no difference after Bonferroni correction(P>0.0125).Under the log-additive model,the rs2237051-2G/G+A/G genotype was associated with an increased risk of SCC(P=0.01;OR=1.42,95%CI 1.08～1.86).However,the association lost statistical significance after Bonferroni correction(P>0.0125).The haplotype rs11569017-rs2237051-rs3733625-rs4444903 has no difference between the two groups(P>0.0125).The stratified analysis revealed no significant associations between the genetic loci and different disease stages(P>0.0125).Conclusion In the Yunnan Han population,the individuals carrying the rs2237051-A allele of the EGF gene have a significantly lower risk of squamous lung cancer,but further functional experiments are needed to verify the protective mechanism.关键词
非小细胞肺癌/表皮生长因子/单核苷酸多态性/相关性Key words
Non-small cell lung cancer/Epidermal growth factor/Single nucleotide polymorphism/Correlation分类
医药卫生引用本文复制引用
姚月婷,李帅,曹杨,林牧,罗正光,陈小波,马千里..表皮生长因子基因遗传多态性与非小细胞肺癌的相关性研究[J].昆明医科大学学报,2025,46(9):89-97,9.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项基金(202201AY070001-141) （202201AY070001-141）
保山市科技计划项目-2023年医学研究联合专项基金(2023bskjylms016) （2023bskjylms016）
