临床误诊误治2025，Vol.38Issue(18)：19-23,30,6.DOI:10.3969/j.issn.1002-3429.2025.18.005
恶性肿瘤患者利妥昔单抗和信迪利单抗相关间质性肺炎临床分析
Clinical analysis of Rituximab-and Sintilimab-induced interstitial lung disease in patients with malignant tumors
摘要
Abstract
Objective Objective To explore the clinical characteristics of Rituximab-induced interstitial lung disease(RILD)and Sintilimab-induced immune checkpoint inhibitor interstitial pneumonia(CIP)in patients with malignant tumors.Methods A retrospective analysis was conducted on the clinical data of 12 patients with malignant tumors who developed RILD or CIP after chemotherapy from January 2010 to December 2024.Results The occurrence time of RILD and CIP in this group was from the 3rd to the 6th cycle of treatment,with a median occurrence time of the 4th cycle.All 12 patients presented with typical chest CT manifestations.Among them,2 patients had no obvious symptoms,and the remaining 10 patients had typical clinical symptoms.Both of the two patients classified as grade 1 were RILD.There were 9 patients with grade 2(3 patients had RILD and 6 patients had CIP),1 patient with grade 3 had CIP,and no patient with grade 4 were observed.Two patients with grade 1 CIP were only closely observed.Nine patients with grade 2 to 3 RILD and CIP were treated with Glucocorticoids combined with Moxifloxacin.One patient with grade 3 RILD was treated with Cephalosporin Antibiotics combined with Glucocorticoids and Yangyin Qingfei pills.The therapeutic effects were satisfactory.Conclusion Patients with malignant tumors should follow the treatment guidelines of the Chinese Society of Clinical Oncology(CSCO)for standardized medication.When RILD and CIP occur,clinicians and clinical pharmacists should cooperate closely,and monitor and use drugs rationally,which can significantly improve the cure rate of RILD and CIP.关键词
弥漫大B细胞淋巴瘤/NK/T细胞淋巴瘤/贲门癌/乳腺浸润癌/利妥昔单抗/信迪利单抗/间质性肺炎/糖皮质激素Key words
diffuse large B-cell lymphoma/NK/T-cell lymphoma/cardia cancer/invasive breast cancer/rituximab/sintilimab/interstitial pneumonia/glucocorticoid引用本文复制引用
侯兰芬,李文静,王永敏,李静,郑云霞,李丽,张宝金,薛倩..恶性肿瘤患者利妥昔单抗和信迪利单抗相关间质性肺炎临床分析[J].临床误诊误治,2025,38(18):19-23,30,6.基金项目
2023年度河北省中医药类科学研究课题计划项目(2023343) （2023343）
