日用化学工业（中英文）2025，Vol.55Issue(9)：1120-1128,9.DOI:10.3969/j.issn.2097-2806.2025.09.005
诺丽精油微乳体系的构建及其稳定性和抑菌活性研究
Study on the construction,stability and antifungal activity of microemulsion system of Noni essential oil
摘要
Abstract
In order to obtain stable oil-in-water(O/W)microemulsion of Noni essential oil(NEO),the water titration method and the pseudo ternary phase diagram method were used to investigate the effects of polyoxyethylene nonionic surfactants,co-surfactants,Km value(the mass ratio of surfactant to co-surfactant),components,and proportions on the microemulsion formation.Meanwhile,the particle size,morphology,electrical conductivity,water solubility,stability,and antifungal activity of the NEO microemulsion were measured to determine their characteristics and physicochemical properties.The results show that castor oil polyethylene glycol 40 as the surfactant,propylene glycol as the co-surfactant,and Km with 3 when the mass ratio of NEO to the mixed surfactant is 7∶3,the water content of the O/W type aqueous phase is 70%,and the NEO microemulsion can be formed.The microemulsion is stable,transparent,and clear with a blue tint.The average particle size is(25.88±4.82)nm with the PDI of 0.177±0.030,and the microemulsion particles are more uniformly dispersed,spherical,and nearly spherical.At the same time,NEO microemulsion has good storage stability,centrifugal stability,and ion concentration stability,and is suitable for use at temperatures below 40℃and in slightly acidic environments.The antifungal effect of NEO microemulsion on Candida tropicalis is better than that of NEO.This study shows that the microemulsion can achieve nanoparticle encapsulation of NEO,providing a good foundation for the widespread application of NEO.关键词
诺丽精油/微乳/拟三元相图/稳定性/热带假丝酵母菌/抑菌活性Key words
Noni essential oil/microemulsion/pseudo ternary phase diagram/stability/Candida tropicalis/antifungal activity分类
化学化工引用本文复制引用
汪雪凤,江芊,范佐旺,谢小丽,于福来,王丹..诺丽精油微乳体系的构建及其稳定性和抑菌活性研究[J].日用化学工业（中英文）,2025,55(9):1120-1128,9.基金项目
海南省重点研发计划项目(ZDYF2024SHFZ132) （ZDYF2024SHFZ132）
海南省重大科技计划项目(ZDKJ2021001) （ZDKJ2021001）
中国热带农业科学院基本科研业务费专项资金(1630032022008) （1630032022008）
