日用化学工业（中英文）2025，Vol.55Issue(9)：1153-1162,10.DOI:10.3969/j.issn.2097-2806.2025.09.009
海藻糖脂在清洁体系中的泡沫和温和性研究
Foam and mildness study of trehalolipid surfactant in rinse off formulations
陈梅 1吴瑶瑶 1夏丹丹 1常晓维 1苏桂珍 2柳晨2
作者信息
- 1. 珀莱雅化妆品股份有限公司,上海 200000
- 2. 南京华狮新材料有限公司,江苏 南京 210009
- 折叠
摘要
Abstract
The paper investigates the foaming and mildness properties of trehalolipids surfactant in rinse-off formulations,comparing it with the traditional nonionic surfactant alkyl-polyglycolide(APG).Both single surfactant and their surfactant complexes are evaluated.And the results show that trehalolipids have significant advantages in reducing surface tension,improving foam performance,and enhancing mildness.For mildness evaluation,multiple methods are employed in the study,including in vitro cell toxicity,inflammatory markers,colorimetric index of mildness CIM,and in vivo method of human skin patch test.The results show that the addition of trehalolipids increases IC50 and reduces the release of inflammatory markers of the binary surfactant system.However,the incorporation of trehalolipids has some negative effects on the skin's lipid barrier function.Skin patch test results indicate that the addition of trehalolipids improves the mildness of surfactant system,particularly in sulfate-free system.Overall,trehalolipids,as nonionic surfactants,presents great potential to replace traditional surfactants in rinse off formulations with enhanced mildness and foam performance.关键词
海藻糖脂/泡沫/温和性/温和性比色指数/zeta电位/人体斑贴试验Key words
trehalolipids/foam/mildness/colorimetric index of mildness CIM/zeta potential/skin patch test分类
化学化工引用本文复制引用
陈梅,吴瑶瑶,夏丹丹,常晓维,苏桂珍,柳晨..海藻糖脂在清洁体系中的泡沫和温和性研究[J].日用化学工业（中英文）,2025,55(9):1153-1162,10.
