肿瘤预防与治疗2025，Vol.38Issue(9)：835-844,10.DOI:10.3969/j.issn.1674-0904.2025.09.011
VEGF-A和Ang2对肿瘤血管生成及免疫细胞的影响
Effects of VEGF-A and Ang2 on Tumor Angiogenesis and Immune Cells
张炜佳 1徐明洋 1赵岳1
作者信息
- 1. 130033 长春,吉林大学中日联谊医院血管外科
- 折叠
摘要
Abstract
Angiogenesis,one of the main features in tumor disease progression,is an important pathway for tumor cells to ingest nutrients and remove metabolic wastes during rapid growth.VEGF family-related signaling pathways and Ang family-related signaling pathways play important roles in tumor angiogenesis.Since the discovery of angiogenic factors,anti-angio-genic therapeutic strategies have been a hot research area in anti-tumor therapy.Immunotherapy,as a newly emerging clini-cal treatment for tumors,has the advantages of significant efficacy,fewer side effects and prolonged patient survival.Howev-er,most cancer patients are not able to benefit from immunotherapy at present.Combining anti-angiogenic therapy and im-munotherapy can improve the effectiveness of immunotherapy and reduce the risk of immune-related adverse effects.In this paper,we will focus on the effects of VEGF-A and Ang2 on tumor angiogenesis as well as tumor immune cells,and summa-rize the data from the literature on the combination of anti-angiogenesis and immunotherapy against tumors in recent years in order to help future research.关键词
血管内皮生长因子/血管生成素/肿瘤血管生成/免疫治疗Key words
Vascular endothelial growth factor/Angiopoietin/Tumor angiogenesis/Immunotherapy分类
医药卫生引用本文复制引用
张炜佳,徐明洋,赵岳..VEGF-A和Ang2对肿瘤血管生成及免疫细胞的影响[J].肿瘤预防与治疗,2025,38(9):835-844,10.
