生物医学工程研究2025，Vol.44Issue(4)：264-269,6.DOI:10.19529/j.cnki.1672-6278.2025.04.09
改性明胶鼻腔止血海绵的制备及其性能研究
Preparation and properties of the modified gelatin nasal hemostatic sponge
摘要
Abstract
In order to improve the antibacterial and hemostatic properties of gelatin nasal hemostatic sponge,we cross-linked and modified gelatin using squid chitosan,then compounded it with polyvinyl alcohol,and finally prepared the modified gelatin nasal hemo-static sponge through freeze-drying.The effect of the hemostatic sponge was explored through tests on its physical and chemical proper-ties,antibacterial properties,hemostatic performance and cytotoxicity.The results showed that the breaking force of the modified gelatin nasal hemostatic sponge was 14.78 N,the expansibility was 3.27 times,the water absorption ratio was 36.5 times,and the average an-tibacterial rates against Staphylococcus aureus and Escherichia coli reached 100%and 98.80%,respectively.The cell survival rate ex-ceeds 90%and the effective hemostasis time is 14 s.The modified gelatin nasal hemostatic sponge prepared exhibits rapid hemostasis,good antibacterial performance,no cytotoxicity and broad clinical application value.关键词
明胶/改性/鱿鱼壳聚糖/膨胀/抑菌Key words
Gelatin/Modification/Squid chitosan/Expand/Bacteriostasis分类
医药卫生引用本文复制引用
李红梅,曲长凤,李博,郑轩杰,赵磊,郈秀菊,韩爱民,张宪科..改性明胶鼻腔止血海绵的制备及其性能研究[J].生物医学工程研究,2025,44(4):264-269,6.基金项目
2023年济南市引进创新团队项目(202228041). （202228041）
