山东中医杂志2025，Vol.44Issue(9)：954-958,5.DOI:10.16295/j.cnki.0257-358x.2025.09.004
"瘀毒"理论指导下从"寒燥成瘀"论治干燥综合征相关间质性肺疾病
Treatment of Sjögren's Syndrome-Associated Interstitial Lung Disease from Perspective of"Cold-Dryness Causing Blood Stasis"Under Guidance of"Blood Stasis-Toxin"Theory
摘要
Abstract
The pathogenesis of Sjogren's syndrome-associated interstitial lung disease(SS-ILD),the most severe respiratory complication of Sjogren's syndrome,has not been fully elucidated.Although Western medicine primarily relies on glucocorticoids combined with immunosuppressants for treatment,its effectiveness remains limited.Based on the holistic syndrome differentiation and treatment system of traditional Chinese medicine,this article proposes that the intermingling of blood stasis and toxin is the core pathogenesis of SS-ILD,and the mutual impairment of cold and dry pathogenic factors is the key to its pathogenesis.External cold stirs up dryness,while internal cold consumes yang qi,resulting in the disorder of the distribution of qi,blood,and body fluids,thus forming a pathological mechanism chain reaction of"extreme cold transforming into dryness-excessive dryness causing blood stasis-prolonged blood stasis transforming into toxin".During the pathological process,the cold pathogen stagnates and blocks the collateral vessels,the dry pathogen injures body fluids and causes the lung lobes to wither and atrophy,and the mutual binding of blood stasis and toxins accelerates the formation of masses in the lung collaterals.Therefore,for the treatment of SS-ILD,the therapeutic principles can be warming yang and moistening dryness,promoting blood circulation to remove blood stasis and detoxifying,so that when yang qi is properly distributed,yin fluid will recover spontaneously,and when cold is dispelled and dryness is eliminated,blood stasis and toxins will disappear naturally.关键词
干燥综合征/间质性肺疾病/瘀毒/寒燥/温阳润燥/化瘀解毒/阳中求阴Key words
Sjögren's syndrome/interstitial lung disease/blood stasis-toxin/cold-dryness/warming yang and moistening dryness/promoting blood circulation to remove blood stasis and detoxifying/seeking yin within yang分类
医药卫生引用本文复制引用
牟洪雨,张伟.."瘀毒"理论指导下从"寒燥成瘀"论治干燥综合征相关间质性肺疾病[J].山东中医杂志,2025,44(9):954-958,5.基金项目
国家中医药管理局科技司共建科技项目(编号:GZY-KJS-SD-2023-037) （编号:GZY-KJS-SD-2023-037）
山东省重点研发计划项目(编号:2024CXPT015) （编号:2024CXPT015）
山东省自然科学基金项目(编号:ZR2021LYZ031) （编号:ZR2021LYZ031）
