有色金属材料与工程2025，Vol.46Issue(4)：28-40,13.DOI:10.13258/j.cnki.nmme.20240107001
Au纳米颗粒形貌调控工艺及SERS性能研究
Tailoring Au nanoparticle morphology for enhanced SERS performance:process optimization and characterization
摘要
Abstract
Rapid and accurate detection of acute myocardial infarction(AMI)can significantly enhance patient survival rates.While cardiac troponin I(cTnI)and myoglobin(MyO)serve as conventional biomarkers,miRNA(MicroRNA)has emerged as a crucial early diagnostic biomarker for heart attacks.However,current routine immunodetection methods,such as real-time fluorescence quantitative polymerase chain reaction(PCR),exhibit limited sensitivity and are time-consuming,hindering the achievement of high-sensitivity quantitative miRNA analysis.Surface Enhanced Raman Scattering(SERS)stands out as an exceptional fingerprint diagnostic technology,offering ultra-sensitivity,rapid response,and qualitative and quantitative analytical capabilities.In this study,the correlation between performance and modulation factors was explored through the manipulation of various morphologies of the noble metal Au.Leveraging the electromagnetic field enhancement and chemical enhancement mechanisms,we designed a simple and easily manufacturable efficient gold nanospheres(Au NSs)NSs SERS biosensing substrate.This substrate was successfully employed for the gradient concentration testing of miRNA,demonstrating remarkably low detection limits and high sensitivity.关键词
急性心肌梗死/miRNA/表面增强拉曼散射/金纳米颗粒/生物检测Key words
acute myocardial infarction/miRNA/surface-enhanced Raman scattering/gold nanoparticles/bioassays分类
化学化工引用本文复制引用
田悦诚,何斌,王丁..Au纳米颗粒形貌调控工艺及SERS性能研究[J].有色金属材料与工程,2025,46(4):28-40,13.基金项目
上海市自然科学基金面上项目(19ZR1435200) （19ZR1435200）
