有色金属材料与工程2025，Vol.46Issue(4)：41-48,8.DOI:10.13258/j.cnki.nmme.20240315001
基于引入疏水官能团调节MOF涂层的水稳定性和抗菌性能研究
Study on the water stability and antibacterial properties of MOF coatings regulated by introducing hydrophobic functional groups
摘要
Abstract
In the biomedical field,metal-organic frameworks(MOF)have attracted much attention due to their excellent design-ability and functionality.However,the stability of MOF in water medium is poor,and it is easy to degrade in acidic environment,which has become a difficult problem restricting its clinical application.In this study,electrodeposition and dip coating techniques were used to optimize the stability of MOF by introducing hydrophobic functional groups.On the titanium alloy to construct a kind of layered double hydroxide(LDH)and the surface of zeolite imidazole skeleton-8(ZIF-8)consisting of double coating.LDH not only plays a protective role,but also strengthens the interface bonding strength between the bottom layer and the surface layer ZIF-8.ZIF-8 acts like a layer of armor,effectively blocking the invasion of corrosive ions through microporous defects.the use of zinc base MOF and raloxifene hydrochloride(RHT),the synergistic effect between the pure titanium surface construct both drug load and stability enhancement of multi-functional coating.The experiment shows that the coating was able to achieve continuous release of Zn2+ions and RHT molecules for more than 14 days.The effective integration of MOF and RHT improves the stability of MOF in water environment.关键词
TA4/MOF涂层/电沉积处理/雷洛昔芬/水稳定性Key words
pure titanium/MOF coating/electrodeposition treatment/raloxifene/water stability分类
矿业与冶金引用本文复制引用
柴宇臻,马凤仓,宋文煊..基于引入疏水官能团调节MOF涂层的水稳定性和抗菌性能研究[J].有色金属材料与工程,2025,46(4):41-48,8.基金项目
国家自然科学基金资助项目(51771119) （51771119）
上海市自然科学基金资助项目(17ZR1419600) （17ZR1419600）
