实用肿瘤杂志2025，Vol.40Issue(5)：391-399,9.DOI:10.13267/j.cnki.syzlzz.2025.060
错配修复功能完整和(或)微卫星稳定型局部进展期直肠癌患者短程放疗序贯化疗联合免疫治疗的新辅助治疗专家共识(2025版)
Expert consensus on neoadjuvant therapy with short-course radiotherapy followed by chemotherapy combined with immunotherapy for patients with mismatch repair-proficient/microsatellite stable locally advanced rectal cancer(2025 edition)
摘要
Abstract
Rectal cancer is one of the most common malignant tumors in China,with more than half of patients diagnosed at a lo-cally advanced stage.Currently,the standard treatment for locally advanced rectal cancer(LARC)primarily involves neoadju-vant chemoradiotherapy followed by radical surgery.The advent of immune checkpoint inhibitors has revolutionized the neoadjuvant treatment landscape for mismatch repair-deficient/microsatellite instability-high(dMMR/MSI-H)rectal cancer.However,the vast majority of rectal cancer patients exhibit mismatch repair-proficient/microsatellite stable(pMMR/MSS)status and show poor re-sponsiveness to immunotherapy.In recent years,multiple studies have demonstrated that a neoadjuvant treatment model combin-ing short-course radiotherapy followed by chemotherapy and immunotherapy can improve the complete response rate in pMMR/MSS LARC patients.Nevertheless,controversies persist regarding patient selection,efficacy evaluation,adverse event management,post-operative adjuvant therapy,and follow-up strategies.In light of this,the Colorectal Surgery Group of the Surgery Branch of the Chi-nese Medical Association,in collaboration with the Colorectal and Anal Surgery Committee of the Chinese Research Hospital As-sociation,the Chinese Colorectal Research Consortium,and related experts,has developed this consensus document by referencing domestic and international research advancements.The aim is to provide standardized guidance for the clinical application of this treatment approach.关键词
局部进展期直肠癌/微卫星稳定状态/短程放疗/免疫治疗/完全缓解Key words
locally advanced rectal cancer/microsatellite stable/short-course radiotherapy/immunotherapy/complete response引用本文复制引用
中华医学会外科学分会结直肠外科学组,中国研究型医院学会结直肠肛门外科专委会,中国结直肠临床研究协作组,陶凯雄,张涛,池畔,肖毅,章真,金晶..错配修复功能完整和(或)微卫星稳定型局部进展期直肠癌患者短程放疗序贯化疗联合免疫治疗的新辅助治疗专家共识(2025版)[J].实用肿瘤杂志,2025,40(5):391-399,9.基金项目
国家自然科学基金项目(82272732,82373123,82473237,82473248) （82272732,82373123,82473237,82473248）
中央高水平医院临床科研专项(2022-PUMCH-C-027) （2022-PUMCH-C-027）
中华国际医学交流基金会项目(HYXH2025036) （HYXH2025036）
湖北省重点研发项目(SHFZ202400031) （SHFZ202400031）
福建省自然科学资金项目(2023J01099,2023J05144) （2023J01099,2023J05144）
福建省科技创新联合资金项目(2020Y9071,2024Y9290,2024Y9261) （2020Y9071,2024Y9290,2024Y9261）
深圳市医学研究专项资金项目(C2301001) （C2301001）
华中科技大学附属协和医院核心医疗技术揭榜挂帅项目(2024JBGS1004,2025JBGS1003) （2024JBGS1004,2025JBGS1003）
