时珍国医国药2025，Vol.36Issue(17)：3208-3213,6.DOI:10.70976/j.1008-0805.SZGYGY-2025-1702
炙红芪-醋莪术对结肠炎相关结肠癌小鼠肠道免疫的影响
Effects of Honey-processed Radix Hedysari+vinegar-processed Rhizoma Curcumae(炙红芪-醋莪术)on intestinal immunity in mice with colitis-associated colorectal cancer
摘要
Abstract
Objective To investigate the effects of Honey-processed Radix Hedysari+vinegar-processed Rhizoma Curcumae(炙红芪-醋莪术,RHRC)on intestinal immunity in mice with colitis-associated colorectal cancer(CAC).Methods 40 C57BL/6 mice were randomly divided into the control group,azoxymethane/dextran sodium sulfate group(model group),sulfasalazine positive control group,and the RHRC(4∶1)group.The CAC model was induced by AOM and DSS in the other groups.The rats in the positive control group and the drug group were treated with sulfasalazine suspension and RHRC(4∶1)extract,respectively,from the beginning of the experi-ment.DAI scores were calculated,and spleens were removed for determination of the expression of T cell subsets CD4+,CD8+.The CD4+/CD8+ratio in the spleen of the model group was significantly decreased.Results Compared with the blank group,the percentage of CD4+T cells and CD4+/CD8+ratio in the spleen of the model group were significantly decreased(P＜0.01),and the percentage of CD19 B cells was significantly decreased(P＜0.01).Compared with the model group,the percentage of CD4+T cells,CD4+/CD8+ratio and CD19 B cells in the spleen of the HRCR-treated group were significantly increased(P＜0.05 or 0.01).Conclusion RHRC can increase the ratio of CD4+/CD8+and the percentage of CD19 B cells,ameliorate the immune deficiency caused by CAC,and main-tain the immune balance.The mechanism may be related to SCFAs in activating the GPR43-mediated ERK-NF-κB signaling path-way.关键词
炙红芪-醋莪术/结肠炎相关结肠癌/短链脂肪酸/细胞外信号调节激酶-核转录因子-κB/作用机制Key words
Honey-processed Radix Hedysari+vinegar-processed Rhizoma Curcumae(炙红芪-醋莪术)/Colitis-associated colorectal cancer(CAC)/Short chain fatty acids/Extracellular signal-regulated kinase-nuclear factor-kappa B/Mechanism of action分类
医药卫生引用本文复制引用
吕瑞龙,高飞云,窦芬瑜,柴梦娜,王毛毛,马定财,王哲,李越峰..炙红芪-醋莪术对结肠炎相关结肠癌小鼠肠道免疫的影响[J].时珍国医国药,2025,36(17):3208-3213,6.基金项目
国家自然科学基金(81960713 （）
82160750) （）
甘肃省教育厅产业支撑计划项(2021CYZC-21) （2021CYZC-21）
甘肃省科技计划(创新基地与人才计划)基础研究创新群体项目(21JR7RA569) （创新基地与人才计划）
甘肃省人才重点项目(2024RCXM77) （2024RCXM77）
高校产业支撑计划项目(024CYZC-41) （024CYZC-41）
甘肃省联合科研基金项目(24JRRA882) （24JRRA882）
甘肃中医药大学研究生"创新创业基金"项目(2025CXCY-034) （2025CXCY-034）
