现代医药卫生2025，Vol.41Issue(9)：2054-2057,2062,5.DOI:10.3969/j.issn.1009-5519.2025.09.008
基于胆汁酸-法尼醇X受体轴探讨中医药对非酒精性脂肪性肝病脂代谢的研究进展
Research progress of traditional Chinese medicine on lipid metabolism of non-alcoholic fatty liver disease based on bile acid-farnesol X receptor axis
摘要
Abstract
Non-alcoholic fatty liver disease(NAFLD)is a clinicopathologic syndrome,which is usually accompanied by metabolic disorders such as obesity,hyperlipidemia,and hyperglycemia.Farnesoid X Receptor(FXR)can regulate human lipid metabolism,and bile acid is its most important endogenous receptor.In recent years,the bile acid-FXR axis had become a hot research mechanism for the treatment of NAFLD.Traditional Chinese medicine is safe and effective in clinical application because of its multi-target and multi-pathway char-acteristics.At present,the research on the treatment of NAFLD from the perspective of bile acid-FXR receptor axis is also increasing.This article introduced the mechanism of bile acid-FXR receptor axis and its effect on lipid metabolism and the research progress of traditional Chinese medicine on lipid metabolism of NAFLD.关键词
非酒精性脂肪性肝病/法尼醇X受体/胆汁酸/脂代谢/中医药/综述Key words
Non-alcoholic fatty liver disease/Farnesol X receptor/Bile acids/Lipid metabolism/Tra-ditional Chinese medicine/Review分类
医药卫生引用本文复制引用
张浩岩,梁得稳,高望..基于胆汁酸-法尼醇X受体轴探讨中医药对非酒精性脂肪性肝病脂代谢的研究进展[J].现代医药卫生,2025,41(9):2054-2057,2062,5.基金项目
天津市卫生健康委员会中医中西医结合项目(2023028) （2023028）
天津市教委科研计划项目(2023KJ171) （2023KJ171）
天津中医药大学第二附属医院"育才计划"科技项目(YC-ZD202304). （YC-ZD202304）
