现代医药卫生2025，Vol.41Issue(9)：2063-2067,5.DOI:10.3969/j.issn.1009-5519.2025.09.010
利拉鲁肽与度拉糖肽治疗对超重2型糖尿病患者胃排空的影响比较
Comparison of the effects of Liraglutide and Dulaglutide treatment on gastric emptying in overweight patients with type 2 diabetes mellitus
摘要
Abstract
Objective To compare the differences in the effects of Liraglutide and Dulaglutide treatment on gastric emptying in overweight patients with type 2 diabetes mellitus(T2DM).Methods A total of 82 o-verweight patients with type 2 diabetes mellitus(T2DM)who were outpatients and inpatients in the hospital from January 2022 to June 2023 were selected and randomly divided into the Liraglutide group and the Dula-glutide group using a random number table method,with 41 cases in each group.Gastric emptying was as-sessed using upper gastrointestinal barium meal radiography,and the gastric area of residual barium was measured using the PACS computer system to plot the gastric activity time curve.Changes in gastric area at 0 minutes(S0),half-gastric emptying time(t1/2),and weight before and after treatment were compared between the two groups.Results Gastric emptying was affected in both groups of patients after treatment,with simi-lar increases in S0 and prolongation of t1/2.After 12 weeks of treatment,the increase in gastrointestinal adverse reactions,weight loss,and changes in BMI were similar between the two groups,and the differences were not statistically significant(P>0.05).However,gastrointestinal adverse reactions were more severe in the dula-glutide group at week 2 of treatment,and the difference was statistically significant(P<0.05).Conclusion Both Liraglutide and Dulaglutide affect gastric emptying in overweight patients with T2DM,with similar weight loss effects.Dulaglutide is more likely to cause gastrointestinal adverse reactions in the early stages of treat-ment,which requires attention.关键词
2型糖尿病/超重/胰高血糖素样肽-1受体激动剂/利拉鲁肽/度拉糖肽/胃排空Key words
Type 2 diabetes/Overweight/Glucagon-like peptide-1 receptor agonists/Liraglutide/Dulaglutide/Gastric emptying分类
医药卫生引用本文复制引用
徐晓丽,李刚,罗海洋,尹经霞,余丽,廖涌,桂晶,崔龙..利拉鲁肽与度拉糖肽治疗对超重2型糖尿病患者胃排空的影响比较[J].现代医药卫生,2025,41(9):2063-2067,5.基金项目
重庆市南岸区科卫联合医学科研项目(2021-14、2023-03、2023-04). （2021-14、2023-03、2023-04）
