新发传染病电子杂志2025，Vol.10Issue(4)：27-33,7.DOI:10.19871/j.cnki.xfcrbzz.2025.04.005
中性粒细胞与淋巴细胞比值联合国际标准化比值对乙型肝炎病毒相关慢加急性肝衰竭患者短期预后的预测价值评估
The predictive value of neutrophil-to-lymphocyte ratio and international normalized ratio on short-term prognosis in patients with hepatitis B virus-related acute-on-chronic liver failure
摘要
Abstract
Objective To explore the predictive value of neutrophil-to-lymphocyte ratio(nlr)and international normalized ratio(INR)in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF),aiming to provide simple and practical early assessment indicators for clinical use.Method A retrospective study was conducted on 210 patients with HBV-ACLF who were admitted to the Department of Hepatology at Chengdu Public Health Clinical Medical Center from January 2021 to December 2022.Based on the 28-day follow-up outcomes,the patients were divided into the survival group(n=148)and non-survivor group(n=62).Clinical characteristics and laboratory parameters were compared between the two groups.Multivariate logistic regression analysis was performed to identify factors influencing treatment outcomes in HBV-ACLF patients.Result Compared to the survival group,the non-survival group exhibited significantly higher incidences of complications such as hepatic encephalopathy,gastrointestinal bleeding,and ascites,along with elevated levels of INR and NLR(P＜0.05).Multivariate logistic regression analysis identified NLR,INR,and hepatic encephalopathy as independent risk factors influencing short-term prognosis in HBV-ACLF patients.Further analysis based on NLR and INR quartiles revealed that patients with NLR＞6.73 and INR＞2.45 had significantly increased 28-day mortality rates.Even after adjusting for confounding factors such as age,sex,and complications,NLR and INR remained independent predictors of short-term mortality in HBV-ACLF patients.Conclusion NLR,INR,and hepatic encephalopathy are independent risk factors for short-term prognosis in HBV-ACLF patients.NLR and INR can serve as simple and effective predictive indicators for assessing the early mortality risk in HBV-ACLF patients.关键词
中性粒细胞与淋巴细胞比值/国际标准化比值/乙型肝炎病毒/慢加急性肝功能衰竭/预后Key words
Neutrophil-to-lymphocyte ratio/International normalized ratio/Hepatitis B virus/Acute-on-chronic liver failure/Prognosis分类
医药卫生引用本文复制引用
朱丽,王补云,胡瑞晴,吴蓓,王丽,曾义岚..中性粒细胞与淋巴细胞比值联合国际标准化比值对乙型肝炎病毒相关慢加急性肝衰竭患者短期预后的预测价值评估[J].新发传染病电子杂志,2025,10(4):27-33,7.基金项目
四川省卫生健康委员会科研课题(20PJ225) （20PJ225）
