新发传染病电子杂志2025，Vol.10Issue(4)：40-45,6.DOI:10.19871/j.cnki.xfcrbzz.2025.04.007
9例AIDS合并中枢神经系统马尔尼菲篮状菌感染患者的临床分析
Clinical analysis of 9 cases of AIDS complicated by central nervous system infection with Talaromyces marneffei
摘要
Abstract
Objective To systematically analyze the clinical characteristics of patients with AIDS complicated by central nervous system Talaromyces marneffei(TM)infection,to enhance the effectiveness of early diagnosis,and optimize clinical management strategies.Method A retrospective case analysis was conducted,including 9 patients with AIDS complicated by central nervous system TM infection diagnosed by cerebrospinal fluid(CSF)microbiology at Chest Hospital of Guangxi Zhuang Autonomous Region from January 2021 to November 2024.Clinical data were systematically analyzed.Result The clinical manifestations of the nervous system in patients showed significant heterogeneity,mainly including headache,fever,altered mental status,abnormal mental behavior,and epileptic seizures.CSF examination results showed increased white blood cell count,decreased glucose,decreased chloride,and elevated protein levels in the CSF.Brain MRI showed intracranial infectious lesions and lateral ventricle dilation in all 9 patients.Metagenomic next-generation sequencing(mNGS)of CSF showed a 100%positive detection rate.After treatment with amphotericin B combined with itraconazole/voriconazole and timely initiation of antiretroviral therapy,8 patients had good clinical outcomes,while 1 patient died of multiple organ failure.Conclusion AIDS complicated by central nervous system TM infection is characterized by complex clinical manifestations and poor prognosis.Timely and accurate diagnosis,along with standardized comprehensive treatment,are key to improving clinical outcomes.关键词
获得性免疫缺陷综合征/马尔尼菲篮状菌病/中枢神经系统感染/临床特征/抗真菌治疗Key words
Acquired immunodeficiency syndrome/Marniffei basket bacterial disease/Central nervous system infection/Clinical features/Antifungal therapy分类
医药卫生引用本文复制引用
谢璐蔓,蓝珂,蒙志好,兰双来,温雨虹,黄葵..9例AIDS合并中枢神经系统马尔尼菲篮状菌感染患者的临床分析[J].新发传染病电子杂志,2025,10(4):40-45,6.基金项目
广西高发皮肤真菌病防治关键技术研究与应用示范(桂科AB24010134) （桂科AB24010134）
