新发传染病电子杂志2025，Vol.10Issue(4)：83-88,6.DOI:10.19871/j.cnki.xfcrbzz.2025.04.014
宿主转录组学、影像组学、影像基因组学在耐药结核病诊治中的应用
Application of host transcriptomics,radiomics and radiogenomics in the diagnosis and treatment of drug-resistant TB
摘要
Abstract
Tuberculosis(TB)has long been a major challenge to global public health,and the emergence of drug-resistant tuberculosis(DR-TB)has intensified the severity of TB.DR-TB not only threatens individual health but also imposes significant socio-economic burdens.Currently,the treatment of DR-TB remains dependent on drug therapy.Therefore,rapid,accurate,and convenient diagnostic technologies are crucial for controlling the spread of TB,particularly DR-TB.Advances of transcriptomics offer new hope for the diagnosis of DR-TB.By analyzing the molecular responses of the host to Mycobacterium tuberculosis(MTB)infection,researchers can identify the expression patterns of key genes.This provides new possibilities for the rapid screening and triage of DR-TB cases.Similarly,progress in radiomics has introduced new tools for the diagnosis and monitoring of TB treatment.Radiomics involves extracting high-throughput radiological features from imaging data,enabling the construction of models for diagnosis,prediction,and prognosis,as well as for studying the correlation between imaging data and clinical outcomes.Furthermore,radiogenomics integrates radiomics with genomics to explore the relationship between lesion imaging characteristics and genomic and molecular features.This integration offers innovative methods for non-invasive diagnosis,prognosis assessment,and treatment evaluation.This paper reviews the advancements in host transcriptomics,radiomics,and radiogenomics in the diagnosis and treatment of DR-TB.The aim is to provide new perspectives for research in this field and to deepen our understanding of the application of these technologies in managing DR-TB.关键词
宿主/转录组学/影像组学/影像基因组学/耐药结核病Key words
Host/Transcriptomics/Radiomics/Radiogenomics/Drug-resistant tuberculosis分类
医药卫生引用本文复制引用
宋树林,金观桥..宿主转录组学、影像组学、影像基因组学在耐药结核病诊治中的应用[J].新发传染病电子杂志,2025,10(4):83-88,6.基金项目
南宁市科学研究与技术开发项目(20233069) （20233069）
