厦门大学学报（自然科学版）2025，Vol.64Issue(5)：759-767,9.DOI:10.6043/j.issn.0438-0479.202404002
中药复方疏泄方调节节律系统改善代谢稳态的研究进展
Research progress in the regulation of circadian system by Shuxie formula for improving metabolic homeostasis
摘要
Abstract
[Background]The circadian rhythm system is an intrinsic biological timing mechanism that plays a pivotal role in maintaining metabolic homeostasis.It regulates the periodic fluctuations of various biological processes with precision,ensuring adaptation to environmental cycles and promoting energy efficiency and balance through the coordination of metabolic activities.In traditional Chinese medicine(TCM),the concept of"the liver governing dispersion and regulating vital energy flow"mirrors the intrinsic regulation of human circadian rhythms.Emerging evidence supports the potential of targeting the liver's neuroendocrine functions in diabetes treatment.This review explores the significance of circadian rhythm in metabolic regulation and the alignment of TCM principles with modern scientific findings.[Progress]This review synthesizes current understanding of how Shuxie formula,a TCM,impacts the interplay between circadian rhythms and metabolic homeostasis.The review encompasses a series of studies that elucidate the intricate connections between circadian rhythms and metabolic processes,particularly within the context of diabetes and its complications.1)Sleep deprivation and metabolic dysregulation:Research indicates that sleep deprivation leads to significant metabolic dysregulation,evidenced by perturbations in the circadian gene Bmal1 in the hypothalamic and hepatic tissues of mice.This gene is a key component of the molecular clock,and its disruption can result in a cascade of metabolic imbalances,including altered glucose metabolism and energy homeostasis.2)Modulation of hepatic fibroblast growth factor 21(FGF21)expression:Shuxie formula has demonstrated its efficacy in modulating the expression of hepatic FGF21,a protein known to play a crucial role in metabolic regulation,particularly in response to stress and nutritional status.By normalizing FGF21 levels,Shuxie formula may counteract the metabolic disruptions associated with sleep deprivation,thus restoring metabolic homeostasis.3)Molecular docking insights:Molecular docking studies have provided insights into the potential molecular mechanisms of Shuxie formula's action.The data indicate a significant binding affinity between the key constituents of Shuxie formula and the FGF 21 protein.This suggests that the formula may exert its effects through direct interactions with metabolic regulatory proteins,offering a new perspective on the molecular basis of TCM treatments.4)Restoration of feeding patterns and energy expenditure:In a series of study utilizing a deprivation of light model(CRD)and sleep deprivation model(ASD),Shuxie formula was observed to restore normal feeding patterns and energy expenditure in rhythm-disrupted mice.The formula's treatment led to a normalization of diurnal activity and feeding rhythms,which had been disrupted by the models,and transitioned the energy allocation strategy,recalibrating it to revert to a protein-centric paradigm,indicating a regulatory effect on the metabolic processes.5)Ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS)analysis of active components:Utilizing UPLC-Q-TOF/MS,researchers have identified the main active components of Shuxie formula,including baicalin,schisandrin,and other bioactive constituents.These components are believed to contribute to the pharmacokinetics and metabolic processes of the formula.6)Gene expression and metabolic pathway analysis:Liver RNA sequencing has revealed significant changes in genes related to glucose metabolism in rhythm-disrupted mice.Shuxie formula's intervention has shown potential in modulating these genes,particularly those involved in the PPAR and FOXO signaling pathways,both critical for glucose homeostasis.7)Antioxidant and anti-inflammatory effects:Further studies have suggested that Shuxie formula mediates antioxidant responses through the NRF2 pathway,mitigating oxidative stress in the colon and other tissues.This effect is particularly important in the context of metabolic disorders,where oxidative stress is a common contributing factor.The collective findings from these studies underscore the multifaceted potential of Shuxie formula in addressing rhythm-metabolic dysregulation.By targeting key molecular players and modulating metabolic pathways,the formula offers a promising therapeutic approach.Future research is warranted to dissect the complex mechanisms and optimize the clinical application of this traditional compound formula.[Perspective]Future research should further integrate TCM theory to elucidate the functional medium of"the liver's role in dispersing and discharging"and the efficacy mechanism of Shuxie formula,clarifying the synergistic action between circadian rhythms and metabolic homeostasis.This approach is expected to provide new insights and therapeutic targets for the treatment of disorders involving rhythmic and metabolic dysregulation.关键词
疏泄方/节律系统/代谢稳态Key words
Shuxie formula/circadian system/metabolic homeostasis分类
医药卫生引用本文复制引用
李博,杨叔禹..中药复方疏泄方调节节律系统改善代谢稳态的研究进展[J].厦门大学学报（自然科学版）,2025,64(5):759-767,9.基金项目
国家自然科学基金(T2341012,82074349) （T2341012,82074349）
厦门市医疗卫生指导性项目(3502Z20244ZD1029) （3502Z20244ZD1029）
