湖北科技学院学报（医学版）2025，Vol.39Issue(5)：406-411,6.DOI:10.16751/j.cnki.2095-4646.2025031205
柚皮苷微孔渗透泵片的制备研究
Preparation of Naringin Microporous Osmotic Pump Tablets
摘要
Abstract
Objective To prepare microhole osmotic pump tablets containing naringin and conduct a systematic optimization of the formulation of these tablets.Methods The tablet core was prepared by the dry granulation and tableting method.The Box-Behnken response surface test was performed on the coating solution by three factors:polyethylene glycol 400(PEG400),dibutyl phthalate(DBP)and coating weight gain.The optimal prescription was obtained by combining the results of single factor and Box-Behnken response surface test.Results The optimal formulations of the tablet core were naringin 20mg,lactose 42.9％,sodium chloride 14.3％,hypromellose 4.6％,poly vinylpyr-rolidone 4％,sodium lauryl sulfate 11.4％,and soluble starch 11.4％.The formulations of the coating solution were 3％cellulose acetate,55％polyethylene glycol 400,and 30％dibutyl phthalate,with a coating weight gain of 3％.The results showed that the cumulative release rates of three batches of naringin microporous osmotic pump tablets were all close to 80％at 24h.The experimental results were basically consistent with the model prediction values,with relative errors all less than 5％.This indicates that the microporous osmotic pump tablets prepared according to the determined formulation had stable quality and good reproducibility.The in vitro drug release behavior showed that the naringin microporous osmotic pump tablets released the drug slowly within 24h.Conclusion Naringin microporous permeable tablets pre-pared with optimal prescription have controlled release properties,and can be used as a reference for the research on the new formulation of naringin.关键词
柚皮苷/微孔渗透泵片/单因素实验/Box-Behnken响应面/处方优化Key words
Naringin/Microhole osmotic pump tablets/Single-Factor experiment/Box-Behnken Response surface methodology/For-mulation optimization分类
医药卫生引用本文复制引用
陈媛媛,张瀚镭,舒璟,蒋凯,白育庭,闵清,要辉..柚皮苷微孔渗透泵片的制备研究[J].湖北科技学院学报（医学版）,2025,39(5):406-411,6.基金项目
湖北省教育厅科研计划项目(B2023166) （B2023166）
湖北科技学院博士启动项目(BK202206) （BK202206）
