眼科新进展2025，Vol.45Issue(10)：825-829,5.DOI:10.13389/j.cnki.rao.2025.0142
NF-κB信号通路在新生血管性年龄相关性黄斑变性中的作用研究进展
Research progress on the role of the NF-κB signaling pathway in neovascular age-related macular degeneration
摘要
Abstract
Age-related macular degeneration(AMD)is one of the leading causes of blindness in the elderly.Wet AMD(nAMD)accounts for more than 90％of AMD-related vision loss.Pathologically,nAMD is defined by choroidal neovascu-larization(CNV)and chronic retinal inflammation driven by oxidative stress,complement activation,pro-inflammatory cy-tokines,and overexpression of vascular endothelial growth factor(VEGF).Yet anti-VEGF monotherapy often falls short.The nuclear factor kappa-B(NF-κB)signaling cascade,acting through both canonical and non-canonical pathways,or-chestrates the expression of genes governing immunity,inflammation,apoptosis,and angiogenesis.In nAMD,oxidative stress and complement fragments ignite NF-κB,unleashing a repertoire of pro-inflammatory and pro-angiogenic mediators that fuel CNV.Pharmacologic or genetic suppression of NF-κB dampens both inflammation and neovascularization,attenua-ting experimental CNV.Thus,dissecting the molecular machinery of NF-κB signaling in nAMD may uncover novel combina-tion strategies that enhance therapeutic efficacy and curb anti-VEGF resistance.关键词
新生血管性年龄相关性黄斑变性/NF-κB信号通路/氧化应激/炎症反应/血管生成Key words
neovascular age-related macular degeneration/NF-κB signaling pathway/oxidative stress/inflammatory response/angiogenesis分类
医药卫生引用本文复制引用
张利民,邹刚,孙硕,杨千惠,刘勃实,李筱荣..NF-κB信号通路在新生血管性年龄相关性黄斑变性中的作用研究进展[J].眼科新进展,2025,45(10):825-829,5.基金项目
国家自然科学基金面上项目(编号:82171085) （编号:82171085）
