眼科新进展2025，Vol.45Issue(10)：830-834,5.DOI:10.13389/j.cnki.rao.2025.0143
补体系统在年龄相关性黄斑变性发病机制中的作用及靶向补体治疗的研究进展
The role of the complement system in the pathogenesis of age-related macu-lar degeneration and recent advances in targeted complement therapy
摘要
Abstract
Age-related macular degeneration(AMD)is a chronic degenerative retinal disease that severely impairs pa-tients central vision.Research indicates that the complement system is closely associated with the onset and progression of AMD,playing a key role in its pathogenesis,involving various factors such as genetic risk,inflammatory responses,and oxidative stress.This review summarizes the relationship between complement system activation and AMD,as well as re-cent clinical trials targeting complement-based therapies for AMD,with the aim of providing insights for both basic research and clinical treatment of AMD.关键词
年龄相关性黄斑变性/补体系统/炎症/氧化应激/治疗Key words
age-related macular degeneration/complement system/inflammation/oxidative stress/treatment分类
医药卫生引用本文复制引用
高佳,张梦迪,曲文甲,莫亚..补体系统在年龄相关性黄斑变性发病机制中的作用及靶向补体治疗的研究进展[J].眼科新进展,2025,45(10):830-834,5.基金项目
国家自然科学基金项目(编号:82474581,82274586) （编号:82474581,82274586）
四川省科技厅资助项目(编号:2024YFFK0149) （编号:2024YFFK0149）
