医学信息2025，Vol.38Issue(18)：37-41,5.DOI:10.3969/j.issn.1006-1959.2025.18.008
慢性肾脏病5期非透析患者左心室肥厚危险因素分析
Analysis of Risk Factors for Left Ventricular Hypertrophy in Non-dialysis Patients with Stage 5 Chronic Kidney Disease
摘要
Abstract
Objective To investigate the risk factors of left ventricular hypertrophy(LVH)in non-dialysis patients with stage 5 chronic kidney disease(ND-CKD5),and to provide evidence for the prevention of LVH in patients with ND-CKD5.Methods The clinical data of 255 patients with ND-CKD5 admitted to the Department of Nephrology,the First Affiliated Hospital of Guilin Medical University from February 2022 to March 2023 were included.According to the occurrence of LVH,they were divided into LVH group and NLVH group.The clinical data of the two groups were compared.Multivariate logistic regression was used to analyze the risk factors of LVH in patients with ND-CKD5,and ROC curve was used to analyze the predictors of LVH in patients with ND-CKD5.Results Among the 255 patients with ND-CKD5,125 had LVH,with an incidence of 49.02％.There were significant differences in the history of hypertension,systolic blood pressure,Hb,Ca,P,BUN,cystatin C,β2-MG,CK,D-dimer and iPTH between the two groups(P＜0.05),there was no significant difference in the other indexes between the two groups(P＞0.05).Multivariate Logistic regression analysis showed that history of hypertension,systolic blood pressure,Hb and β2-MG were independent risk factors for LVH in patients with ND-CKD5.ROC curve analysis showed that the area under the ROC curve of systolic blood pressure,Hb and β2-MG in predicting LVH in ND-CKD5 patients was 0.601,0.622 and 0.657,respectively,while the area under the ROC curve of combined prediction of LVH was 0.725,95％CI was 0.663-0.788,sensitivity was 60.80％,and specificity was 76.15％.Conclusion The incidence of LVH is high in patients with ND-CKD5,and systolic blood pressure,Hb and β2-MG are independent risk factors for LVH in patients with ND-CKD5.The combined detection of the above risk factors has good clinical value in predicting the occurrence of LVH.关键词
慢性肾脏病/非透析/左心室肥厚Key words
Chronic kidney disease/Non-dialysis/Left ventricular hypertrophy分类
医药卫生引用本文复制引用
秦菊,马云华,谢敏慧,阳文秀,邓洁,欧俊,廖雪玲..慢性肾脏病5期非透析患者左心室肥厚危险因素分析[J].医学信息,2025,38(18):37-41,5.基金项目
广西壮族自治区卫生健康委自筹经费科研课题(编号:Z-C20230867) （编号:Z-C20230867）
