中国病理生理杂志2025，Vol.41Issue(9)：1674-1684,11.DOI:10.3969/j.issn.1000-4718.2025.09.002
褪黑素通过抑制铁死亡减轻急性心肌梗死
Melatonin alleviated acute myocardial infarction by inhibiting ferroptosis
摘要
Abstract
AIM:To investigate whether melatonin can ameliorate acute myocardial infarction(AMI)by in-hibiting ferroptosis.METHODS:H9C2 cells were cultured in AnaeroPack system with low sugar and serum-free medium for 10 h to construct a cell model of AMI.Then cells were treated with melatonin and ferroptosis inducer erastin.The cell activity,reactive oxygen species(ROS),lipid peroxidation,mitochondrial membrane potential(MMP),and ferroptosis related protein expression were detected.A rat model of AMI induced by isoprenaline(ISO)injection was established to evaluate the effects of melatonin,in which the myocardial infarction size,cardiac injury,pathological changes,oxidative stress,iron ion and ferroptosis related protein expression were examined.RESULTS:Melatonin decreased the oxidative stress,lipid peroxidation and expression of ferroptosis protein in cardiomyocytes induced by hypoxia,but these effects could be impeded by the ferroptosis inducer erastin.Furthermore,in vivo experiments,we also found that melatonin im-proved the myocardial infarction size,cardiac injury,pathological changes,oxidative stress,and alleviated iron ion accu-mulation and ferroptosis.CONCLUSION:The cardioprotective effects of melatonin in AMI are associated with the inhi-bition of ferroptosis.关键词
急性心肌梗死/褪黑素/铁死亡/心脏保护Key words
acute myocardial infarction/melatonin/ferroptosis/cardioprotection分类
医药卫生引用本文复制引用
黄小惠,温伟星,陈鹏,李伟文,李家欢,曹越,胡允兆,黄裕立..褪黑素通过抑制铁死亡减轻急性心肌梗死[J].中国病理生理杂志,2025,41(9):1674-1684,11.基金项目
Supported by Guangdong Medical Research Foundation(No.A2024382),Guangdong Provincial Bureau of Traditional Chinese Medicine research project(No.20231321),and Scientific Research Start Plan of Shunde Hospital,Southern Medical University(No.SRSP2022012 （No.A2024382）
No.SRSP2022016) （）
