中国康复理论与实践2025，Vol.31Issue(9)：1023-1031,9.DOI:10.3969/j.issn.1006-9771.2025.09.005
汉语发展性阅读障碍儿童全脑静息态功能连接的特征分析
Characterisation of whole-brain resting-state functional connectivity in children with Chinese developmental dys-lexia
摘要
Abstract
Objective To examine resting-state whole-brain network connectivity in children with Chinese developmental dyslexia(DD)and typically developing(TD)children using functional near-infrared spectroscopy(fNIRS). Methods From November to December,2024,19 DD children aged six to twelve years in Children's Hospital of Fudan University were enrolled,along with 18 TD children matching age and sex.Regions of interest included frontal cortex(FC),temporal lobe(TL),occipital lobe(OL)and parietal lobe(PL).Resting-state data were acquired by fNIRS for five minutes in both groups.Functional connectivity strength was calculated at rest,and between-group differences in connectivity strength and brain networks were compared,based on the time series of oxyhe-moglobin concentration. Results The whole-brain functional connectivity strength was higher in DD group than in TD group(t=2.100,P<0.05).Connectivity between the right OL-right FC(t=2.426,P<0.05),right OL-left FC(t=2.483,P<0.05),right TL-right FC(t=2.568,P<0.05)and right TL-left FC(t=2.304,P<0.05)were stonger in DD group than in TD group.The major regions exhibiting differences of whole-brain connectivity between two groups were the right dorsolateral prefrontal cortex,right visual association cortex,right frontal cortex,left orbitofrontal cortex,left visual association cortex,left primary visual cortex and right primary motor cortex. Conclusion Children with DD exhibited significantly stronger connectivity in the right occipital and temporal lobes,as well as between these regions and the prefrontal cortex,suggesting possible right-hemispheric compensation for insufficiency in the left-hemisphere reading network.关键词
发展性阅读障碍/功能性近红外光谱技术/静息态/全脑功能连接Key words
developmental dyslexia/functional near-infrared spectroscopy/resting state/whole-brain functional connectivity分类
医药卫生引用本文复制引用
骆丹丹,沈敏,王素娟,邱翁歆,张宇轩,吴蕴,王圣虓..汉语发展性阅读障碍儿童全脑静息态功能连接的特征分析[J].中国康复理论与实践,2025,31(9):1023-1031,9.基金项目
上海市残联科研项目(No.2023ZC1006) Supported by Scientific Research Project of Shanghai Disabled Persons'Federation(No.2023ZC1006) （No.2023ZC1006）
