中国康复理论与实践2025，Vol.31Issue(9)：1050-1056,7.DOI:10.3969/j.issn.1006-9771.2025.09.008
经颅直流电刺激对意识障碍患者脑功能网络方向性连接的影响
Effect of transcranial direct current stimulation on α-band brain connectivity in disorders of consciousness
摘要
Abstract
Objective To investigate the modulatory effects of transcranial direct current stimulation(tDCS)on directional informa-tion flow within the α-band functional brain networks in patients with disorders of consciousness(DoC). Methods From October,2023 to October,2024,30 patients with DoC were recruited from Binzhou Medical University Hospital.They were assigned to minimally conscious state(MCS)group(n=15)and unresponsive wakefulness syndrome(UWS)group(n=15).All the patients received conventional rehabilitation and tDCS at left dorsolater-al prefrontal cortex for four weeks.Ten-minute electroencephalography data were collected before and after treat-ment. Results Two cases dropped out from MCS group.Granger causality(GC)connectivity between the prefrontal and pari-etal regions enhanced in both groups after treatment,particularly in bidirectional pathways between bilateral pre-frontal and parietal regions,as well as between frontocentral and parietal regions,and limbic-central connections.GC connectivity was extensive and bidirectional in MCS group,and localized and unidirectional in UWS group. Conclusion tDCS can enhance directional information flow between bilateral prefrontal and parietal regions in patients with DoC,for promoting recovery of consciousness.Neural plasticity was better in MCS patients than in UWS patients.关键词
意识障碍/经颅直流电刺激/脑电图/格兰杰因果分析Key words
disorders of consciousness/transcranial direct current stimulation/electroencephalography/Granger causality analysis分类
医药卫生引用本文复制引用
李红卫,黄彬彬,朱传花,李伟..经颅直流电刺激对意识障碍患者脑功能网络方向性连接的影响[J].中国康复理论与实践,2025,31(9):1050-1056,7.基金项目
1.山东省自然科学基金项目(No.ZR2022MH063) （No.ZR2022MH063）
2.山东省中医药科技创新面上项目(No.M20244103) Supported by Shandong Provincial Natural Science Foundation(No.ZR2022MH063),and Shandong Provincial Fund for Science and Technology Innovation in Traditional Chinese Medicine(General)(No.M20244103) （No.M20244103）
