中国康复理论与实践2025，Vol.31Issue(9)：1066-1073,8.DOI:10.3969/j.issn.1006-9771.2025.09.010
基于功能性近红外光谱探讨脑机接口对脑卒中患者上肢运动功能障碍的效果
Effect of brain-computer interface on upper limb motor dysfunction in stroke patients based on functional near-infrared spectroscopy
摘要
Abstract
Objective To explore the changes in task-state brain region activation of stroke patients using functional near-infrared spectroscopy(fNIRS)in the treatment of upper limb motor function with brain-computer interfaces(BCI). Methods From April to October,2024,40 stroke patients in Linyi People's Hospital were randomly divided into control group and BCI group,with 20 cases in each group.Both groups received conventional rehabilitation therapy.The control group underwent low-frequency electrotherapy before conventional treatment,while BCI group received BCI therapy before conventional treatment,for four weeks.Fugl-Meyer Assessment-Upper Extremities(FMA-UE)and modified Barthel Index were used to evaluate the upper limbs motor function before and after treatment.A"wrist movement task"was designed to detect the level of oxyhemoglobin(HbO₂)in the regions of interest(ROI)during the task. Results After treatment,the scores of MBI and FMA-UE increased in both groups(|t|>8.904,P<0.001),and were higher in BCI group than in the control group(|t|>2.584,P<0.05).The HbO₂ level in the premotor cortex/sup-plementary motor area(PMC/SMA)increased after treatment in BCI group(t=-3.965,P<0.01),and was high-er in BCI group than in the control group(t=-3.630,P<0.01).The difference of HbO₂ level in PMC/SMA be-fore and after treatment correlated with both the difference of MBI score(r=0.498,P<0.05)and the difference of FMA-UE score(r=0.799,P<0.001). Conclusion BCI can further improve the upper limb motor function of stroke patients on the basis of conventional treat-ment and enhance the cortical activation of PMC/SMA.关键词
脑卒中/脑机接口/上肢/运动功能/功能性近红外光谱Key words
stroke/brain-computer interface/upper limb/motor function/functional near-infrared spectroscopy分类
医药卫生引用本文复制引用
高云汉,侯闪闪,汪鑫煜,朱崇田..基于功能性近红外光谱探讨脑机接口对脑卒中患者上肢运动功能障碍的效果[J].中国康复理论与实践,2025,31(9):1066-1073,8.基金项目
1.山东省重点研发计划项目(No.2024CXGC010603) （No.2024CXGC010603）
2.临沂市重点研发计划项目(No.2024YX0027) Supported by Key Research and Development Program of Shandong Province(No.2024CXGC010603)and Linyi Key Research and Development Program(No.2024YX0027) （No.2024YX0027）
