中国现代医学杂志2025，Vol.35Issue(18)：1-5,5.DOI:10.3969/j.issn.1005-8982.2025.18.001
孟鲁司特钠联合盐酸丙卡特罗在难治性支原体肺炎患儿中的应用效果
Clinical efficacy of montelukast sodium combined with procaterol hydrochloride in children with refractory Mycoplasma pneumoniae pneumonia
摘要
Abstract
Objective To investigate the clinical efficacy of montelukast sodium combined with procaterol hydrochloride in children with refractory Mycoplasma pneumoniae pneumonia(RMPP).Methods A total of 92 children with RMPP admitted to Tianjin People's Hospital from August 2022 to August 2024 were selected and randomly divided into a monotherapy group(n=46)and a combination group(n=46)using the envelope randomization method.The monotherapy group received procaterol hydrochloride alone,while the combination group received montelukast sodium combined with procaterol hydrochloride.The two groups were compared in terms of clinical efficacy,clinical symptom indicators,pulmonary function,inflammatory cytokine levels,and adverse reactions.Results The overall effective rate in the combination group was significantly higher than that in the monotherapy group(P＜0.05).The length of hospital stay,cough relief time,and wheezing disappearance time were all shorter in the combination group compared to the monotherapy group(P＜0.05).The changes in forced expiratory volume in one second(FEV1),forced vital capacity(FVC),maximal mid-expiratory flow(MMEF),and peak expiratory flow(PEF)before and after treatment were greater in the combination group than in the monotherapy group(P＜0.05).Reductions in interleukin(IL)-6,IL-13,IL-17,tumor necrosis factor(TNF)-a,and interferon(IFN)-γ levels before and after treatment were also significantly greater in the combination group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Montelukast sodium combined with procaterol hydrochloride demonstrates significant clinical efficacy in children with RMPP.关键词
难治性支原体肺炎/孟鲁司特钠/盐酸丙卡特罗/肺功能/炎症因子Key words
refractory Mycoplasma pneumoniae pneumonia/montelukast sodium/procaterol hydrochloride/pulmonary function/inflammatory cytokine分类
医药卫生引用本文复制引用
陈倩,刘莹..孟鲁司特钠联合盐酸丙卡特罗在难治性支原体肺炎患儿中的应用效果[J].中国现代医学杂志,2025,35(18):1-5,5.基金项目
天津市自然科学基金面上项目(No:22JCYBJC00210) （No:22JCYBJC00210）
天津市人民医院科研项目(No:Y52D004) （No:Y52D004）
