中国现代医学杂志2025，Vol.35Issue(18)：14-19,6.DOI:10.3969/j.issn.1005-8982.2025.18.003
桔贝合剂联合亚胺培南西司他丁钠治疗社区获得性肺炎伴呼吸衰竭的效果
Effectiveness of Jubei Mixture in combination with imipenem and cilastatin sodium in the treatment of community-acquired pneumonia with respiratory failure
摘要
Abstract
Objective To investigate the effectiveness of Jubei Mixture combined with imipenem and cilastatin sodium in the treatment of community-acquired pneumonia(CAP)with respiratory failure(RF)and its effect on inflammatory factors and blood gas indexes.Methods Eighty-six patients with CAP with RF admitted to our hospital from March 2021 to March 2024 were selected and randomly divided into 43 cases in the observation group and 43 cases in the control group using the odd-even number method.The control group was treated with imipenem and cilastatin sodium,and the observation group was additionally given Jubei Mixture.After 7 days of treatment,the two groups were compared in terms of blood gas indexes,lung function,inflammatory factors,cardiac and renal function,therapeutic efficacy and adverse reactions.Results The differences of partial pressure of oxygen,partial pressure of carbon dioxide,oxygenation index,peak expiratory flow,forced vital capacity,forced expiratory volume in 1 second,and levels of tumor necrosis factor-α and soluble triggering receptor expressed on myeloid cells-1 before and after treatment in the observation group were all greater than those in the control group(P＜0.05).The effective rate in the observation group was higher than that in the control group(P＜0.05).There was no significant difference in the incidence of total adverse reactions between the observation group and the control group(P＞0.05).Conclusion Jubei Mixture combined with imipenem and cilastatin sodium for the treatment of CAP with RF promotes the recovery of pulmonary function and demonstrates a favorable safety profile.关键词
社区获得性肺炎/桔贝合剂/亚胺培南西司他丁/肺功能/炎症因子/血气指标Key words
community-acquired pneumonia/Jubei Mixture/imipenem and cilastatin/pulmonary function/inflammatory factors/blood gas indexes分类
医药卫生引用本文复制引用
殷豆豆,邢娟..桔贝合剂联合亚胺培南西司他丁钠治疗社区获得性肺炎伴呼吸衰竭的效果[J].中国现代医学杂志,2025,35(18):14-19,6.基金项目
江苏省卫生健康委员会科研项目(No:Ym2023071) （No:Ym2023071）
