中国现代医学杂志2025，Vol.35Issue(18)：42-47,6.DOI:10.3969/j.issn.1005-8982.2025.18.007
乳酸化修饰在肿瘤免疫逃逸中的研究进展
Research progress on the role of lactylation in tumor immune evasion
摘要
Abstract
Lactylation,as a novel post-translational modification mechanism,has increasingly attracted attention for its role in tumor immune evasion in recent years.Lactylation can be classified into histone and non-histone lactylation.It promotes tumor immune evasion through multiple mechanisms,including metabolic reprogramming of immune cells,promotion of macrophage polarization,regulation of immune cell metabolism and function,and modulation of immune cell signaling pathways.In the context of immunotherapy,lactylation is closely associated with resistance to PD-1 inhibitors and CAR-T cell therapy.Targeting lactate dehydrogenase or specific lactylation sites can significantly enhance the efficacy of immunotherapeutic interventions.This review explores the interplay between lactylation and other post-translational modifications,as well as the potential application prospects of targeting lactylation as a new strategy for tumor immunotherapy.These findings provide a novel perspective for a deeper understanding of the mechanisms of tumor immune evasion and offer a theoretical basis for the development of innovative immunotherapeutic approaches.关键词
肿瘤免疫/乳酸化修饰/免疫逃逸/免疫治疗Key words
tumor immunity/lactylation/immune evasion/immunotherapy分类
医药卫生引用本文复制引用
李梅,何佶芮,熊秋霞..乳酸化修饰在肿瘤免疫逃逸中的研究进展[J].中国现代医学杂志,2025,35(18):42-47,6.基金项目
国家自然科学基金(No:82460505) （No:82460505）
云南省科技厅技术创新人才项目(No:202105AD160005) （No:202105AD160005）
云南省/昆医大附一院重大科技专项(No:2023zdpy05) （No:2023zdpy05）
