中国现代医学杂志2025，Vol.35Issue(18)：60-66,7.DOI:10.3969/j.issn.1005-8982.2025.18.010
地夸磷索钠联合强脉冲光治疗在糖尿病相关干眼症中的应用
Application of diquafosol sodium combined with intense pulsed light therapy in the treatment of diabetes-related dry eye disease
摘要
Abstract
Objective To explore the therapeutic effects of diquafosol sodium combined with intense pulsed light therapy in patients with diabetes-related dry eye disease.Methods A total of 86 patients with diabetes-related dry eye admitted to Handan First Hospital from January 2021 to January 2023 were selected.They were divided into two groups by the random number table method,with 43 cases in each group.Patients in the control group were treated with diquafosol sodium eye drops,while the observation group was additionally treated with intense pulsed light.The treatment effective rate was compared between the two groups.The levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-17(IL-17)]in tears were detected before and after treatment.The Schirmer I test(SIT)was performed before and after treatment,and the tear film break-up time(BUT)and tear meniscus height were measured.The meibomian gland secretion score,meibomian gland dropout score,tear film lipid layer thickness,Ocular Surface Disease Index(OSDI)score,Standard Patient Evaluation of Eye Dryness(SPEED)score,and corneal Fluorescein Staining(FLS)score were compared between the two groups before and after treatment.Results The overall treatment effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the levels of TNF-α,IL-6,and IL-17 were all decreased in both groups(P＜0.05),and the differences of them before and after treatment were higher in the observation group than in the control group(P＜0.05).After treatment,both groups showed increases in SIT,BUT,and tear meniscus height(P＜0.05),and the changes in these parameters from pre-to post-treatment were greater in the observation group than in the control group(P＜0.05).Both groups exhibited decreased meibomian gland secretion and dropout scores(P＜0.05)and increased tear film lipid layer thickness after treatment(P＜0.05),while the pre-to post-treatment differences in these meibomian gland parameters were greater in the observation group compared to the control group(P＜0.05).Additionally,OSDI,SPEED,and corneal FLS scores decreased in both groups after treatment(P＜0.05),with the observation group showing greater improvements than the control group(P＜0.05).Conclusion The combination of diquafosol sodium and intense pulsed light is effective in improving the therapeutic outcomes and ocular symptoms of patients with diabetes-related dry eye disease.关键词
糖尿病相关干眼症/地夸磷索钠/强脉冲光/睑板缺失率Key words
diabetes-related dry eye disease/diquafosol sodium/intense pulsed light/meibomian gland dropout rate分类
医药卫生引用本文复制引用
要青清,薛佳佳,宗志峰..地夸磷索钠联合强脉冲光治疗在糖尿病相关干眼症中的应用[J].中国现代医学杂志,2025,35(18):60-66,7.基金项目
河北省卫生健康委员会医学科学研究计划项目(No:20232040) （No:20232040）
2023年邯郸市(医疗卫生类)科技计划项目(No:23422083040ZC) （医疗卫生类）
