中国畜牧杂志2025，Vol.61Issue(10)：61-71,11.DOI:10.19556/j.0258-7033.20241014-03
羊精原干细胞体外培养及诱导分化的研究进展
Research Progress on In Vitro Culture and Differentiation Induction of Spermatogonial Stem Cells in Sheep and Goats
摘要
Abstract
As important agricultural economic animals and biomedical models,sheep and goats play a significant role in the research on in vitro culture and induced differentiation of spermatogonial stem cells(SSCs),which is of great significance for the development of genetic breeding and reproductive medicine.However,this field currently still faces numerous challenges,including difficulties in long-term in vitro maintenance of SSCs,insufficient efficiency of isolation and purification technologies,unclear regulatory mechanisms of differentiation pathways,and the precision and safety of gene editing technologies.This paper systematically reviews the research progress in construction strategies of sheep and goat SSCs in vitro culture systems,induced differentiation methods,and their molecular mechanisms in recent years.Meanwhile,it discusses the potential applications of related cutting-edge technologies,providing a theoretical reference for optimizing the in vitro culture system of SSCs,improving differentiation efficiency,and expanding their applications in animal husbandry breeding and regenerative medicine.关键词
羊精原干细胞/体外培养/诱导分化Key words
Sheep and Goat Spermatogonial Stem Cells/In Vitro Culture/Induced Differentiation分类
农业科技引用本文复制引用
何宣辉,康丹菊,郑隆清,甘尚权,安立龙,周光现..羊精原干细胞体外培养及诱导分化的研究进展[J].中国畜牧杂志,2025,61(10):61-71,11.基金项目
广东海洋大学博士启动基金(R20045、R19066) （R20045、R19066）
广东海洋大学2022年度质量工程建设项目-动物科学专业(PX-16223472) （PX-16223472）
2022年广东省乡村振兴战略专项资金种业振兴项目(2022-XDY-00-009) （2022-XDY-00-009）
湛江市科技计划项目-山羊养殖技术服务与推广(A23085) （A23085）
