中国药理学通报2025，Vol.41Issue(10)：1801-1807,7.DOI:10.12360/CPB202504018
类风湿关节炎滑膜微环境中免疫细胞对异常骨重塑的调控研究进展
Advances in regulation of dysregulated bone remodeling by immune cells within rheumatoid arthritis synovial microenvironment
摘要
Abstract
Rheumatoid arthritis(RA)is characterized by bidi-rectional bone remodeling imbalance,clinically termed the "high resorption-low formation" paradox,stemming not only from osteoclast hyperactivation but also critically involving pro-found suppression of osteoblast differentiation and function.No-tably,this suppression cannot be fully attributed to osteoclast hyperactivity;synovium-resident immune cells exert a pivotal regulatory influence through distinct mechanisms.This review systematically examines how synovial immune cells orchestrate bone remodeling in RA through both paracrine cytokine networks and direct cell-cell communication with bone lineage cells,thereby perturbing physiological homeostasis and driving patho-logical progression.These mechanistic revelations yield innova-tive perspectives on RA pathogenesis,positioning immune-medi-ated osteoimmune dysregulation as a promising therapeutic fron-tier for targeted intervention.关键词
类风湿关节炎/骨重塑/成骨细胞/破骨细胞/免疫细胞/骨代谢Key words
rheumatoid arthritis/bone remodeling/osteoblast/osteoclast/immune cells/bone metabolism分类
医药卫生引用本文复制引用
贺俊杰,尧忠柳,胡明月,黄红,蔡雄..类风湿关节炎滑膜微环境中免疫细胞对异常骨重塑的调控研究进展[J].中国药理学通报,2025,41(10):1801-1807,7.基金项目
国家自然科学基金项目(No 82274506) （No 82274506）
