中国药理学通报2025，Vol.41Issue(10)：1807-1812,6.DOI:10.12360/CPB202503094
致幻剂在创伤后应激障碍中的应用及相关神经生物学机制
Application of hallucinogens in post-traumatic stress disorder and the related neurobiological mechanisms
摘要
Abstract
Excessive stress has a significant impact on an indi-vidual's physical and mental health and quality of life.Al-though psychotherapy is commonly used for post-traumatic stress disorder(PTSD),pharmacotherapy plays an important role in the treatment of severe PTSD.At present,there are limited types of approved medications for PTSD,and their efficacy and safety have certain limitations,such as low remission rates,high relapse rates,and increased behavioral risks.Studies have shown that hallucinogens such as psilocybin and ketamine can enhance neuroplasticity,modulate brain network connections,and regulate the immune system by interacting with different re-ceptors,so as to effectively alleviate PTSD symptoms such as anxiety,depression and fear,showing great potential in PTSD treatment.However,these hallucinogens are not yet widely used in clinical practice.This review summarizes the effects and neu-robiological mechanisms of hallucinogens in the treatment of stress-related symptoms,aiming to provide references for the clinical treatment of PTSD.关键词
致幻剂/创伤后应激障碍/受体/神经可塑性/大脑网络/免疫调节Key words
hallucinogens/post-traumatic stress disorder/re-ceptors/neuroplasticity/brain networks/immune regulation分类
医药卫生引用本文复制引用
王悦颖,孙毅,杨静玉,苏瑞斌..致幻剂在创伤后应激障碍中的应用及相关神经生物学机制[J].中国药理学通报,2025,41(10):1807-1812,6.基金项目
军事医学研究院保密项目 （）
