中国药理学通报2025，Vol.41Issue(10)：1813-1817,5.DOI:10.12360/CPB202502091
选择性磷酸二酯酶抑制剂防治炎症性肠病的作用机制研究进展
Research progress on mechanism of action of selective phosphodiesterase inhibitors in prevention and treatment of inflammatory bowel disease
摘要
Abstract
Inflammatory bowel disease(IBD)is a common di-gestive system disease with an increasing morbidity year by year.Its pathological mechanisms have not been fully clarified,and there are currently no ideal or effective curative methods.Phos-phodiesterase(PDE)can regulate intracellular cAMP/cGMP levels to mediate downstream signaling pathways,participating in various pathophysiological processes.In recent years,the po-tential efficacy of PDE inhibitors in the treatment of IBD has gradually attracted attention.This article reviews the pharmaco-logical effects and mechanisms of selective PDE subtype inhibi-tors in the prevention and treatment of IBD,providing references for further research of IBD therapeutic drugs.关键词
炎症性肠病/磷酸二酯酶抑制剂/环磷酸腺苷/环磷酸鸟苷/炎症反应/氧化应激/分子机制Key words
inflammatory bowel disease/phosphodiesterase in-hibitor/cyclic adenosine monophosphate/cyclic guanosine monophosphate/inflammatory response/oxidative stress/molec-ular mechanism分类
医药卫生引用本文复制引用
高娜,王雨,刘振华,杨为民,肖创..选择性磷酸二酯酶抑制剂防治炎症性肠病的作用机制研究进展[J].中国药理学通报,2025,41(10):1813-1817,5.基金项目
国家自然科学基金资助项目(No 82460012) （No 82460012）
云南省科技厅项目(No 202401AT070173,202301AY070001-175) （No 202401AT070173,202301AY070001-175）
