中国药物评价2025，Vol.42Issue(4)：290-294,5.
环硅酸锆钠治疗血液透析伴慢性高钾血症患者的有效性及安全性研究
Efficacy and Safety of Sodium Zirconium Cyclosilicate in the Treatment of Hemodialysis Patients with Chronic Hyperkalemia
摘要
Abstract
Objective:To study the efficacy and safety of sodium zirconium cyclosilicate in hemodialysis patients with chronic hyperkalemia.Methods:Patients with hemodialysis complicated by chronic hyperkalemia who visited the First People's Hospital from March to October 2023 were selected for prospective study and risk factor analysis.The experimental group was treated with sodium zirconium cyclosilicate,while the control group was given a low-potassium diet.The potassium-lowering effect and the occurrence of adverse reactions were observed in both groups.Results:In terms of effectiveness:after treatment,the serum potassium level of the experimental group was lower than that of the control diet group(P＜0.05),and the serum potassium value of 50％patients in the experimental could be stable within the normal range,while there was no statistical difference between the two groups in other indicators(P＞0.05).Meanwhile,the use of RAASI drugs,dialysis vintage,and creatinine level are risk factors affecting the potassium-lower-ing efficacy of sodium zirconium cyclosilicate.In terms of safety:the incidence of adverse reactions was compared between the two groups,and the results showed no statistical difference(P＞0.05).Conclusion:Sodium zirconium cyclosilicate therapy for hemodial-ysis patients with chronic hyperkalemia can effectively control serum potassium levels,and with good safety,and attention should be paid to the impact of relevant risk factors during its use.关键词
环硅酸锆钠/血液透析/高钾血症/有效性/安全性Key words
Sodium zirconium cyclosilicate/Hemodialysis/Hyperkalemia/Efficacy/Safety分类
医药卫生引用本文复制引用
毛盼盼,安兴宇,宋沧桑,李兴德..环硅酸锆钠治疗血液透析伴慢性高钾血症患者的有效性及安全性研究[J].中国药物评价,2025,42(4):290-294,5.基金项目
云南省卫生健康委员会医学领军人才培养项目(L-2018012) （L-2018012）
昆明市卫生健康委员会带头人才培养项目[2022-SW(带头)-32] （带头）
云南省教育厅科学研究基金项目(2024J0294) （2024J0294）
