摘要
Abstract
Objective:To evaluate the effects of liraglutide combined with acarbose and metformin on glucose and lipid metabolism,islet function,inflammation,and oxidative stress in patients with type 2 diabetes mellitus(T2DM).Methods:A retrospective controlled analysis was conducted on 92 T2 DM patients treated at our hospital from April 2022 to December 2024(effect sized=0.8,α=0.05,β=0.2).The patients were divided into the control group(acarbose+metformin,n=46)and the experimental group(combined with liraglutide,n=46).Changes in glucose metabolism indicators(FPG,HbA1C),blood lipid parameter(TG,TC,LDL-C,HDL-C),islet function parameters(HOMA-IR、ISI、HOMA-β),and biomarkers related to inflammation(NLRP3)and oxidative stress(MDA,GSH-PX,SOD)were compared between the two groups before and after treatment.The incidence of adverse reactions was also recorded.Results:The total effective rate in the experimental group was higher than that in the control group(93.48％vs 78.26％,P＜0.05).After treatment,levels of FPG,HbA1c,TG,TC,and LDL-C decreased and HDL-C increased in both groups of patipats,with greater improvements observed in the experimental group(P＜0.05).The experimental group showed a significant advantage in improving islet function parameters:greater reduction in HOMA-IR and greater increases in ISI and HOMA-β compared to the control group(P＜0.05).Meanwhile,the experimental group exhibited greater reductions in the inflammatory marker NLRP3 and the oxidative stress marker MDA,as well as greater increases in GSH-PX and SOD(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Liraglutide combined with the acarbose and metformin can more effectively improve glucose and lipid metabolism in T2DM patients,reduce insulin resistance,and promote the recovery of islet β-cell function,while also suppressing inflammatory responses and oxidative damage,and with good safety.关键词
2型糖尿病(T2DM)/利拉鲁肽/阿卡波糖/二甲双胍/胰岛功能/糖脂代谢Key words
Type 2 diabetes mellitus(T2DM)/Liraglutide/Acarbose/Metformin/Islet function/Glucose and lipid metabolism分类
医药卫生
