中华骨质疏松和骨矿盐疾病杂志2025，Vol.18Issue(4)：400-409,10.DOI:10.3969/j.issn.1674-2591.2025.04.002
绝经后女性LRP5基因rs4988331和rs599083位点多态性与骨质疏松症的关系
Association of LRP5 gene polymorphisms rs4988331 and rs599083 with osteoporosis in postmenopausal women
摘要
Abstract
Objective To evaluate the association between polymorphisms at rs4988331 and rs599083 loci of the low-density lipoprotein receptor-related protein 5(LRP5)gene and postmenopausal osteoporosis(OP)in women in Shihezi,Xinjiang and to provide a scientific basis for the prevention and treatment of OP.Methods Participants were classified into three groups based on bone mineral density(BMD)measured by dual energy X-ray absorptionmetry(DXA):normal bone mass group(n=57),osteopenia group(n=53),and OP group(n=32).Data collected included age,years since menopause,and body mass index(BMI).Clinical biochemical indicators of glucose,lipid,and bone metabolism were measured.Single nucleotide polymorphisms(SNPs)at LRP5 gene loci were detected using mass spectrometry.Results(1)Compared to the normal bone mass group,the osteopenia and OP groups had signifi-cantly higher age and years since menopause(P<0.01).(2)Compared to the normal bone mass group,the osteope-nia group had higher glycosylated hemoglobin(HbA1c)(P<0.05).The OP group showed significantly lower triglycer-ide(TG),triglyceride-glucose(TyG)index,TyG-BMI index(P<0.05).Compared to the osteopenia group,the OP group had lower TG,TyG-BMI index(P<0.05).(3)There were no significant differences in type 2 diabetes mellitus(T2DM)prevalence or polymorphism distributions of rs4988331 and rs599083 among the groups(P>0.05).(4)In the normal bone mass group,individuals with the CC genotype at rs4988331 had higher fasting blood glucose(FBG)and lower serum creatinine(Cr)compared to those with the CT genotype(both P<0.05).In the abnormal bone mass group,the CC genotype was associated with higher FBG,HbA1c,L1-4 BMD,and TyG-waist circumference(WC)in-dex(all P<0.05).In the normal bone mass group,individuals with the TT genotype at rs599083 had higher low-densi-ty lipoprotein cholesterol(LDL-C)but lower BMD at L1-4 and FN than those with GG/GT genotypes(all P<0.05).(5)Increased age was a risk factor for decreased BMD at L1-4 and FN(P<0.05),while a higher TyG-BMI index was a protective factor for BMD loss at FN and L1-4.Conclusion In postmenopausal women in Xinjiang,SNPs at the rs4988331 locus of the LRP5 gene is associated with OP and T2DM,while SNPs at rs599083 is associated with OP de-velopment.关键词
骨质疏松/2型糖尿病/低密度脂蛋白受体相关蛋白5/基因多态性Key words
osteoporosis/type 2 diabetes mellitus/low density lipoprotein receptor-related protein 5/gene pol-ymorphisms引用本文复制引用
黎娅,李军,李思源,杜晴晴,卢韵秋,李亚欣,祝叶丞,孙传冰..绝经后女性LRP5基因rs4988331和rs599083位点多态性与骨质疏松症的关系[J].中华骨质疏松和骨矿盐疾病杂志,2025,18(4):400-409,10.基金项目
新疆生产建设兵团科技项目(2021AB031) （2021AB031）
石河子大学兵团指导性科技项目计划(2022ZD044) （2022ZD044）
石河子大学国际科技合作推进计划(GJHZ202206) （GJHZ202206）
