中华骨质疏松和骨矿盐疾病杂志2025，Vol.18Issue(4)：447-452,6.DOI:10.3969/j.issn.1674-2591.2025.04.007
儿童起病肿瘤性佝偻病一例报告
Case report of tumor-induced rickets in a child
齐文婷 1姜艳 1夏维波1
作者信息
- 1. 100730 北京,中国医学科学院 北京协和医学院 北京协和医院内分泌科 国家卫生健康委员会内分泌重点实验室,疑难、重症与罕见病全国重点实验室
- 折叠
摘要
Abstract
Tumor-induced osteomalacia/rickets(TIO/TIR)is rare in children and adolescents,making differ-entiation from hereditary hypophosphatemic rickets/osteomalacia particularly challenging.Here we reported a case of a 4-year-old girl diagnosed with rickets,with laboratory findings of hypophosphatemia,hyperphosphaturia,normal serum cal-cium,and extremely elevated alkaline phosphatase(ALP).Phosphorus and active vitamin D supplementation showed limited effect.Imaging revealed distinctive cup-shaped deformities in the hands and wrists,metaphyseal irregularities in both knees,and patchy low-density lesions in the right femur.Octreotide SPECT/CT detected a somatostatin receptor-posi-tive lesion in the distal right femur,with MRI confirming a tumor,indicating TIR.The level of phosphorus returned to nor-mal after the surgery,and bone pain and deformities improved significantly.This case underscored the need to consider ac-quired causes of hypophosphatemic rickets in children,particularly to distinguish it from hereditary causes and prevent ad-verse outcomes.关键词
低血磷性佝偻病/肿瘤性骨软化症/佝偻病/遗传性低血磷性佝偻病/鉴别诊断Key words
hypophosphatemic rickets/tumor-induced osteomalacia/rickets/hereditary hypophosphatemic rick-ets/differential diagnosis分类
医药卫生引用本文复制引用
齐文婷,姜艳,夏维波..儿童起病肿瘤性佝偻病一例报告[J].中华骨质疏松和骨矿盐疾病杂志,2025,18(4):447-452,6.
