浙江医学2025，Vol.47Issue(17)：1814-1817,4.DOI:10.12056/j.issn.1006-2785.2025.47.17.2025-1110
NF-κB/IL-6/STAT3信号通路对结直肠腺瘤性息肉的作用研究
Research on the effects of the NF-κB/IL-6/STAT3 signaling pathways on adenomatous polyps
摘要
Abstract
Objective To explore the differences in expression of the nuclear factor-κB(NF-κB)/interleukin-6(IL-6)/signal transducer and activator of transcription 3(STAT3)signaling pathways in colorectal adenomatous polyps and hyperplastic polyps,and analyze its potential role in the occurrence and development of intestinal tumors.Methods Polyp tissue specimens from 3 patients each with colorectal adenomatous polyps and hyperplastic polyps who underwent endoscopic polyp removal at Hangzhou Third People's Hospital from April to June 2024 were retrospectively selected,as well as mucosal tissue specimens of colorectal inflammation from 3 patients with colorectal mucosal inflammation.The expression levels of NF-κB,IL-6,and STAT3 mRNA and protein were measured using Western blotting and quantitative real-time PCR(qRT-PCR),and the expression levels were compared among the different tissue types.Results No statistically significant differences were found in NF-κB and IL-6 mRNA levels among colorectal adenomatous polyps,hyperplastic polyps and inflammatory mucosal tissues(all P＞0.05).However,STAT3 mRNA expression level showed significant differences(P＜0.05).Specifically,STAT3 mRNA level was higher in adenomatous polyp tissues compared to inflammatory mucosal tissues(P＜0.05).There were statistically significant differences in the protein expression levels of NF-κB,IL-6 and STAT3 among colorectal adenomatous polyps,hyperplastic polyps and inflammatory mucosal tissues(all P＜0.05).Pairwise comparisons between groups revealed higher protein levels of STAT3,NF-κB,and IL-6 in adenomatous polyp tissues than those in inflammatory mucosal tissues(all P＜0.05).Differences between other groups were not statistically significant(all P＞0.05).Conclusion NF-κB,IL-6,and STAT3 might promote the occurrence and development of colorectal adenomatous polyps.Consequently,targeted studies on the NF-κB/IL-6/STAT3 signaling pathway could provide new treatment options for colorectal tumors.关键词
结直肠息肉/结直肠腺瘤/核因子-κB/白细胞介素-6/信号转导和转录激活因子3Key words
Colorectal polyps/Colorectal adenoma/Nuclear factor-κB/Interleukin-6/Signal transducer and activator of transcription 3引用本文复制引用
俞瑾,李珍,周辰,李春霞,李华铭..NF-κB/IL-6/STAT3信号通路对结直肠腺瘤性息肉的作用研究[J].浙江医学,2025,47(17):1814-1817,4.基金项目
浙江省中医药科技计划项目(2022ZA138) （2022ZA138）
杭州市科技计划引导项目(20121231Y039) （20121231Y039）
