摘要
Abstract
Objective To explore the relationship between the levels of serum death-associated protein kinase 1(DAPK1)and total tau(T-tau)protein and cognitive dysfunction in patients with type 2 diabetes mellitus(T2DM).Methods A total of 178 patients with T2DM who were diagnosed and treated at the Affiliated Hospital of Xuzhou Medical University from May 2024 to January 2025 were selected.According to whether the patients had cognitive dysfunction,they were divided into cognitive dysfunction group(88 cases)and control group(90 cases).Based on Montreal cognitive assessment(MoCA)score,patients with cognitive dysfunction were further divided into severe group(MoCA score＜10 points,24 cases);moderate group(10 points ≤MoCA score ≤17 points,31 cases),and mild group(18 points ≤MoCA score＜26 points,33 cases).The levels of serum DAPK1 and T-tau proteins were detected by enzyme-linked immunosorbent assay,and the risk factors were analyzed by Logistic regression.Spearman correlation analysis was used to evaluate the correlation between T-tau protein,DAPK1 and the severity of cognitive dysfunction.Results The age,duration of diabetes mellitus,proportion of hyperlipidemia,fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglobin,T-tau protein,and DAPK1 of patients in cognitive dysfunction group were significantly higher than those in control group,while the educational level was significantly lower than that in control group(P＜0.05).Logistic regression analysis showed that the duration of diabetes mellitus,T-tau protein,DAPK1,and glycated hemoglobin were all independent risk factors for cognitive dysfunction in patients with T2DM(P＜0.05).The T-tau protein and DAPK1 of patients in severe group were significantly higher than those in mild group and moderate group(P＜0.001).Spearman correlation analysis showed that DAPK1 and T-tau proteins were positively correlated with severity of cognitive dysfunction(P＜0.05).Conclusion The duration of diabetes mellitus,glycated hemoglobin,DAPK1 and T-tau protein are all independent risk factors for cognitive dysfunction in patients with T2DM.The levels of DAPK1 and T-tau protein are related to the severity of cognitive dysfunction and can be used as potential markers for risk assessment.关键词
2型糖尿病/认知功能障碍/死亡相关蛋白激酶1/总tau蛋白/相关性Key words
Type 2 diabetes mellitus/Cognitive impairment/Death-associated protein kinase 1/Total tau protein/Correlation分类
医药卫生
