中医临床研究2025，Vol.17Issue(16)：44-49,6.DOI:10.3969/j.issn.1674-7860.2025.16.007
基于数据挖掘探讨郭蓉娟教授治疗重症肌无力的用药规律及临床经验
Prof.GUO Rongjuan's medication rules and experience in treating myasthenia gravis based on data mining
摘要
Abstract
Objective:To deeply explore the medication patterns and clinical experience of Prof.GUO Rongjuan in treating myasthenia gravis,providing a basis and new ideas for the treatment of myasthenia gravis in traditional Chinese medicine(TCM).Methods:The real world medical record data about myasthenia gravis patients in the outpatient clinic of Prof.GUO Rongjuan from Dongfang Hospital,Beijing University of Chinese Medicine from January 1,2021,to March 1,2024,were collected to establish a database,and data standardization processing was carried out.IBM SPSS Modeler 18.0 software was used for medicine association rule analysis,and IBM SPSS Statistics 26.0 software was used for hierarchical cluster analysis.Results:A total of 187 prescriptions were included,involving 118 Chinese medicines,with a cumulative usage of 2 848 times.There were 26 high-frequency Chinese medicines(the frequency of usage was not less than 30 times),and the top 5 were Huangqi(Radix Astragali,183 times),Dangshen(Radix Codonopsis,162 times),Baizhu(Rhizoma Atractylodis Macrocephalae)stir-fried with wheat bran(150 times),Shichangpu(Rhizoma Acori Tatarinowii,139 times),and Yujin(Radix Curcumae,115 times).In terms of medicinal properties and tastes,the sweet medicine(1 615 times)and warm medicine(1 200 times)were the main types,and the tropism meridians were mainly the spleen meridian(1 388 times),liver meridian(1 358 times),and lung meridian(1 203 times).In terms of clinical efficacy,the tonify medicine(1 905 times)were the main type.The association rule analysis showed that Huangqi and Dangshen were core medicines,and Huangqi-Dangshen-Baizhu stir-fried with wheat bran was an essential tripartite medicine combination.The cluster analysis classified the included Chinese medicines into 7 categories.Conclusion:In the treatment of myasthenia gravis,Prof.GUO Rongjuan takes the fundamental principle of strengthening the spleen and replenishing Qi(气),emphasizes the simultaneous treatment of the liver and spleen,and the regulation of the spleen and kidney,and takes into account the elimination of phlegm and activation of blood circulation,and the soothing of the liver and relieving depression,forming a characteristic comprehensive treatment system with multiple targets and multiple pathways.This study objectively reveals the medication patterns of Prof.GUO Rongjuan in the treatment of myasthenia gravis with the help of data mining technology,providing important references for the treatment of myasthenia gravis in TCM,and demonstrating the innovative application value of data mining in TCM research.关键词
数据挖掘/重症肌无力/用药规律/健脾益气Key words
Data mining/Myasthenia gravis/Medication pattern/Strengthening the spleen and replenishing Qi分类
医药卫生引用本文复制引用
林禹舜,郭蓉娟..基于数据挖掘探讨郭蓉娟教授治疗重症肌无力的用药规律及临床经验[J].中医临床研究,2025,17(16):44-49,6.基金项目
第六批北京市级中医药专家学术经验继承工作项目. （）
