中医临床研究2025，Vol.17Issue(16)：50-57,8.DOI:10.3969/j.issn.1674-7860.2025.16.008
针药结合治疗卵巢储备功能下降的临床中药及选穴规律分析
An analysis of clinical medication and acupoint selection rules of TCM in the treatment of diminished ovarian reserve based on data mining
摘要
Abstract
Objective:Based on clinical randomized controlled trial studies,the clinical medication and acupoint selection rules of traditional Chinese medicine in the treatment of ovarian reserve dysfunction(DOR)were analyzed for providing a reference for acupuncture plus medication therapy and other therapies for the treatment of DOR.Methods:The clinical literature on treating DOR by acupuncture plus Chinese medicine from the inception to October 2024 was retrieved from CNKI,Wanfang Data,and VIP.After standardized data processing,Excel was used to establish a database of acupuncture plus Chinese medicine for the treatment of DOR,and medication frequency analysis was carried out.The Chinese medicine association rule and cluster analyses were performed by IBM SPSS 18.0,and the complex network analysis was performed by Cytoscape 3.6.0 software.Results:A total of 32 relevant articles were screened out,and 48 Chinese medicine prescriptions and 41 acupoint prescriptions were extracted,involving 88 Chinese medicines and 46 acupoints.The high-frequency Chinese medicines used were Shudihuang(Radix Rehmanniae Preparata),Danggui(Radix Angelicae Sinensis),and Tusizi(Semen Cuscutae).The medicinal properties were mainly warm or cold,the medicinal taste was mainly sweet,supplemented by bitter and pungency,and the tropism meridians were mainly liver meridian,kidney meridian,and spleen meridians.The high-frequency acupoints included Guanyuan acupoint(RN4),Sanyinjiao acupoint(SP6),and Shenshu acupoint(BL23),among which the combination with the highest correlation was Danggui-Guanyuan acupoint.Through the cluster analysis,7 clusters were obtained,and the basic acupoint prescriptions were Guanyuan acupoint-Sanyinjiao acupoint-Zusanli acupoint(ST36)-Shenshu acupoint-Qihai acupoint(RN6)-Zhongji acupoint(RN3)-Dahe acupoint(KI12)-Guilai acupoint(ST29)-Zigong acupoint(EX-CA1)-Taichong acupoint(LR3)-Ciliao acupoint(BL32).The basic Chinese medicine prescription was composed of Danggui,Shudihuang,Tusizi,Baishao(Radix Paeoniae Alba),Shanzhuyu(Fructus Corni),and Shanyao(Rhizoma Dioscoreae).Conclusion:DOR is mainly caused by congenital and acquired deficiency,the disease is mainly located in the kidneys,spleen,and stomach,and the property of the disease is mainly kidney deficiency,accompanied by blood deficiency and blood stasis.In terms of the treatment with Chinese medicine prescriptions,tonifying medicines and promoting blood circulation to remove blood stasis medicines were high-frequency medicines,which were mostly used for warming and tonifying,namely nourishing body and promoting blood circulation were applied simutaneously.The acupoints of Ren meridian(任脉)and Foot Yangming Stomach Meridian(足阳明胃经)are selected mainly,reflecting that the selected acupoints not only can nourish kidney essence but also tonify Qi(气)and blood,and dredge blood vessels,which conforms to the basic pathogenesis of kidney deficiency,and can be used as a basic combination of Chinese medicine and acupoints for the clinical treatment of DOR.关键词
卵巢储备功能下降/针刺/中药/取穴规律/数据挖掘Key words
Diminished ovarian reserve/Acupuncture/Chinese medicine/Acupoint selection rule/Data mining分类
医药卫生引用本文复制引用
王安然,于冬丽,周桂瑶,李蕊,尹爱兵..针药结合治疗卵巢储备功能下降的临床中药及选穴规律分析[J].中医临床研究,2025,17(16):50-57,8.基金项目
山东省卫生健康委员会中医药科技项目(Z-2023104) （Z-2023104）
青岛市医疗卫生优秀人才培养项目资助 （）
青岛市卫生健康委员会中医药科研计划项目(2020-zyy035). （2020-zyy035）
