中医临床研究2025，Vol.17Issue(16)：76-81,6.DOI:10.3969/j.issn.1674-7860.2025.16.011
基于阴阳、营卫学说探讨时钟基因对伤口愈合昼夜节律的影响
The influence of clock genes on the circadian cycles of wound healing based on the theories of Yin-Yang,and Ying-Wei
摘要
Abstract
Circadian rhythms are ubiquitous and one of the basic functions of organisms.They are based on the interaction of multiple clock genes and achieve periodic fluctuations through sophisticated and complex regulatory networks,which have a profound impact on the physiological and pathological processes of organisms.Modern medical research shows that a variety of cell synergies are involved in the process of wound healing,playing their unique functions in each stage of wound healing and providing favorable conditions for wound healing.Further in-depth studies have revealed that relevant cell functions are regulated by clock genes,which in turn affect the process and quality of wound healing by modulating pivotal biological behaviours such as cell proliferation,migration and differentiation.From the perspective of traditional Chinese medicine,wound healing is closely related to the transformation of Yin(阴)and Yang(阳)in circadian rhythm and the changes of Ying and Wei[nutritive Qi(气)and defensive Qi].The alteration of circadian rhythm induces a reciprocal transformation between Yin and Yang,which in turn affects the operation and distribution of nutritive Qi and defensive Qi.Nutritive Qi and defensive Qi is complementary to Yin and Yang,which jointly constitutes a vital mechanism that promotes wound healing.Wound healing is affected when Yin and Yang are in a state of imbalance and nutritive Qi and defensive Qi exhibits discordance.In this paper,the mechanism of clock genes regulating wound healing process and the relationship between clock genes and Yin-yang,and nutritive Qi and defensive Qi are analyzed,it is revealed that clock genes affect cell biological behaviour to regulate wound healing,and there is substantial interoperability between clock gene regulatory mechanisms and Yinyang,and nutritive Qi and defensive Qi.This finding not only offers a novel perspective on wound healing,but also provides a new target for the intervention of traditional Chinese medicine on wound healing.It is expected to develop a more effective treatment plan by regulating clock genes or other interventions those are carried out based on the theories of Yinyang,nutritive Qi and defensive Qi,which has important clinical application value and broad application prospects.关键词
昼夜节律/时钟基因/伤口愈合/阴阳/营卫Key words
Circadian rhythm/Clock gene/Wound healing/Yin-Yang/Ying-Wei分类
医药卫生引用本文复制引用
方佳乐,王林华..基于阴阳、营卫学说探讨时钟基因对伤口愈合昼夜节律的影响[J].中医临床研究,2025,17(16):76-81,6.基金项目
湖南省中医药管理局项目(A2024024) （A2024024）
长沙市自然科学基金项目(kq2208207). （kq2208207）
