中医临床研究2025，Vol.17Issue(17)：22-29,8.DOI:10.3969/j.issn.1674-7860.2025.17.004
基于真实世界数据挖掘中医药治疗稳定性冠状动脉粥样硬化性心脏病合并焦虑抑郁状态的多中心研究
A multicenter study on traditional Chinese medicine in the treatment of stable coronary artery disease plus anxiety and depressive states based on real-world data mining
摘要
Abstract
Objective:To explore the distribution of syndrome elements in patients with stable coronary artery disease(SCAD)plus anxiety and/or depression states and the traditional Chinese medicine differentiation and treatment rules based on real-world data.Methods:The clinical diagnosis and treatment data of 316 patients with SCAD plus anxiety and/or depression state in 10 Grade Ⅲ A hospitals across the country was collected for medication frequency statistics and association rule analysis of medicines included to analyze the initial TCM prescriptions of patients in the three groups,namely,the combined anxiety group,the combined depression group,and the combined anx-iety and depression group.Results:In the patients with SCAD plus anxiety and/or depression state,blood stasis,Qi(气)deficiency,and Yin(阴)deficiency were the main syndrome elements of patients combined with anxiety state;blood stasis,Qi deficiency,and phlegm turbidity were the main syndrome elements of patients combined with depression state;and Qi deficiency,blood stasis,and phlegm turbid-ity were the main syndrome elements of patients combined with anxiety and depression state.A total of 316 prescriptions involving 236 Chinese medicines were included,with a cumulative medication frequency of 4 265.For patients combined with anxiety state,the medici-nal properties and flavors of Chinese medicines used were mainly bitter and cold,which mostly were absorbed by liver meridian and heart meridian,and the top 5 Chinese medicines in order of medication frequency were Danshen(Radix Salviae Miltiorrhizae),Dangshen(Radix Codonopsis),Yujin(Radix Curcumae),Zhigancao(Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle),and Chaihu(Radix Bupleuri).For patients combined with depression state,the medicinal properties and flavors of Chinese medicines used were mainly sweet and warm,which were mostly absorbed by lung meridian and spleen meridian,and the top 5 Chinese medicines in order of medication frequency were Fuling(Poria),Danshen,Dangshen,Zhigancao,and Huangqi(Radix Astragali).For patients combined with anxiety and depression states,the medicinal property and flavors of Chinese medicines used were mainly sweet and warm,which were mostly absorbed by spleen meridian and liver meridian,and the top 5 Chinese medicines in order of medication frequency were Baizhu(Rhizoma Atractylodis Macro-cephalae),Chuanxiong(Rhizoma Chuanxiong),Zhiqiao(Fructus Aurantii),Danggui(Radix Angelicae Sinensis),Fushen(Poria cum Radix Pini)and Taoren(Semen Persicae)(the last two medicines were tied for the fifth place).Conclusion:In the real-world data mining,the core pathogenesis of SCAD plus anxiety and/or depression is Qi deficiency and blood stasis.The clinical treatment should be based on tonifying Qi and activating blood,and auxiliary medicines should be added or subtracted according to the different syndromes.关键词
稳定性冠状动脉粥样硬化性心脏病/焦虑抑郁状态/中医证素/用药规律/真实世界研究Key words
Stable coronary artery disease/Anxiety and depression states/Traditional Chinese medicine syndrome element/Medica-tion rule/Real-world research分类
医药卫生引用本文复制引用
李婷,郝艺芳,岳晴晴,苗含颖,李圣耀..基于真实世界数据挖掘中医药治疗稳定性冠状动脉粥样硬化性心脏病合并焦虑抑郁状态的多中心研究[J].中医临床研究,2025,17(17):22-29,8.基金项目
国家中医心血管病临床医学研究中心专项科研基金(CMC2022001) （CMC2022001）
山西省中医药管理局科研项目(2022ZYYC031) （2022ZYYC031）
山西中医药大学2023年研究生创新创业项目(2023CX003) （2023CX003）
山西中医药大学2022年研究生优硕创新计划(2022YS004). （2022YS004）
