中医临床研究2025，Vol.17Issue(20)：1-10,10.DOI:10.3969/j.issn.1674-7860.2025.20.001
双样本孟德尔随机化研究哮喘与气虚表型的相关性
The correlation between asthma and Qi deficiency phenotype based on two-sample Mendelian randomization analysis
摘要
Abstract
Objective:To explore the correlation between asthma and Qi(气)deficiency phenotype by two-sample Mendelian randomization analysis.Methods:The asthma data set was mainly derived from studies conducted by Valette K et al.Qi deficiency constitution type was mainly manifested by main physical characteristics of whole body fat-free mass(WBFFM),frailty index(FI),frequency of tiredness and lethargy in last 2 weeks(FT),upper respiratory tract infection(URTI),dizziness,and memory loss.FI data was obtained from the study of Janice L Atkins,WBFFM and FT data was downloaded from the IEU Open GWAS database,and RUTI,dizziness,and memory loss data was downloaded from the Finnish genetic database.The R language Two-Sample MR software package was used for Mendelian randomization analysis.IVW method was used as the main analysis method,and the reliability was verified by MR-Egger,Weighted median,Simple mode,and Weighted mode.Heterogeneity test,sensitivity analysis,and pleiotropy analysis were performed.Results:The IVW analysis results showed that asthma was negatively correlated with WBFFM(OR=0.988 5,95%CI=0.979 2～0.997 9),and positively correlated with FI(OR=1.117 3,95%CI=1.095 0～1.139 1),dizziness(OR=1.076 0,95%CI=1.017 0～1.138 2),URTI(OR=1.121 4,95%CI=1.080 9～1.163 3),and the results were significant.Asthma was positively correlated with memory loss(OR=1.015 8,95%CI=0.910 0～1.133 9)and FT(OR=1.010 4,95%CI=0.999 0～1.021 2,P=0.056 1),but the outcome was not significant.Heterogeneity tests indicated the absence of heterogeneity,sensitivity analyses all showed robustness,and there were no pleiotropy.Conclusion:Asthma can increase the risk of multiple Qi deficiency phenotypes.In the diagnosis and treatment of asthma,it is necessary to promptly identify whether patients have secondary Qi deficiency bias,and timely intervene it when there is a need,so as to prevent disease from changing.关键词
哮喘/气虚/孟德尔随机化Key words
Asthma/Qi deficiency/Mendel randomization分类
医药卫生引用本文复制引用
杨敏,戴和森,黄平富..双样本孟德尔随机化研究哮喘与气虚表型的相关性[J].中医临床研究,2025,17(20):1-10,10.基金项目
安徽省中医药传承创新科研项目(2022CCYB09) （2022CCYB09）
新安医学与中医药现代化研究所"揭榜挂帅"项目(2023CXMMTCM005) （2023CXMMTCM005）
滁州市科技计划项目(2023ZD026). （2023ZD026）
