中医临床研究2025，Vol.17Issue(20)：20-29,10.DOI:10.3969/j.issn.1674-7860.2025.20.003
基于网络药理学和网络毒理学探讨黄药子对甲状腺结节及肝损伤的毒效机制研究
Exploration on the action mechanism of deleterious effects of Huangyaozi on thyroid nodules and liver injury based on network pharmacology and network toxicology
摘要
Abstract
Objective:To preliminarily explore the action mechanism of Huangyaozi(Rhizoma Dioscoreae)in treating thyroid nodule and its deleterious influence on liver injury through network pharmacology and network toxicology.Methods:The related components of Huangyaozi and their corresponding targets were collected from the TCMSP.The target gene names were retrieved from the UniProt database.The targets related to thyroid nodules and hepatotoxicity were retrieved from GeneCards and OMIM databases,which were cross-linked with medicine targets respectively to obtain the common targets of medicine targets and disease targets.The common targets were imported into the STRING database for protein interaction analysis,and a visual analysis was performed by the Cytoscape software.The R language software was used to conduct GO biological analysis and KEGG signaling pathway enrichment analysis for core targets.Results:After screening,15 chemical components and 203 targets of Huangyaozi were obtained.There were 130 intersection targets of Huangyaozi and thyroid nodules,and 180 associated pathways.There were 178 intersection targets of Huangyaozi and hepatotoxicity,and 192 associated pathways.Huangyaozi could treat thyroid nodules by regulating AGE-RAGE,IL-17,TNF and other signal pathways through targets such as AKT1,TP53,TNF,IL-6,and IL-1B.The hepatotoxicity of Huangyaozi was closely related to regulating AGE-RAGE,IL-17,TNF,and other signaling pathways through AKT1,TNF,IL-6,TP53,IL-1B and other targets.Conclusion:The therapeutic effect of Huangyaozi on thyroid nodules and its deleterious influence on liver injury involve multiple components,targets,and signaling pathways,providing new ideas for subsequent in-depth research.关键词
黄药子/甲状腺结节/肝损伤/毒效机制Key words
Huangyaozi/Thyroid nodules/Liver injury/Deleterious effect mechanism分类
医药卫生引用本文复制引用
刘媛媛,王静,张家瑞,赵悦,高静,庞敏..基于网络药理学和网络毒理学探讨黄药子对甲状腺结节及肝损伤的毒效机制研究[J].中医临床研究,2025,17(20):20-29,10.基金项目
中国中医药信息学会2024年度科研课题项目(CACMS-KY-2024042) （CACMS-KY-2024042）
辽宁省自然科学基金联合基金面上项目(2023-MSLH-145). （2023-MSLH-145）
